肾移植患者用药依从性及其影响因素的调查分析

目的:探寻影响肾移植患者术后用药依从性的主要因素,并为在该类患者中针对性开展药学服务提供依据。方法:查阅国内、外文献设计调查问卷,对在山东省千佛山医院定期随诊的肾移植患者进行问卷调查和访谈,了解其对药学服务的需求;根据问卷调查结果中的用药依从性得分将患者分为用药依从组和用药非依从组,采用卡方检验、t检验和Logistic回归等方法,研究肾移植患者中用药依从性的影响因素。结果:55例肾移植患者中用药不依从者占50.9%;性别、职业、文化程度、"医保"形式,2组比较差异无统计学意义(P>0.05);2组患者年龄、肾移植知识、术后时间和用药安全知识比较,差异有统计学意义(P<0.05);Logis-tic回归分析表明,术后时间和用药安全知识是影响患者用药依从性的主要因素。结论:肾移植患者中用药不依从现象普遍存在,药师应针对性地开展药学服务,提高患者的用药依从性,提高移植肾的长期存活率。

Investigation and Analysis of Medication Compliance and Influencing Factors in Patients Underwent Transplantation

OBJECTIVE： To investigate the main influential factors tion, and to provide reference for the development of pharmaceutical of medication compliance in patients after renal transplantacare for this type of patients. METHODS： Questionnaires were designed according to foreign and domestic literatures. Post-transplantation patients at return visit in Qianfoshan Hospital were investigated with questionnaires and interviewed to understand requirements of pharmaceutical care; then the patients were divided into medication compliance group and non-compliance group according to medication compliance scores of questionnaire. Chi-square test, t-test and Logistic regression analysis were used to study influential factors of medication compliance in patients af- ter renal transplantation. RESULTS： Of total 55 patient, ratio of medication noncompliance was 50.9%, there＇s no significant difference between 2 groups in sex, occupation, education and medical insurance type （P〉0.05） ; there was statistical significance between 2 groups in age and renal transplantation knowledge, the time after surgery and knowledge of the safety of drug use （P〈 0.05） ; Logistic regression analysis indicated that the time after surgery and knowledge of the safety of drug use were main influencing factors of medication compliance. CONCLUSION： The non-compliance generally exist in post-transplantation patients, pharmacists should supply pharmaceutical care for them to improve medication compliance and the survival rate of transplanted kidney.