| Markov模型应用于药物经济学中效用值的计算及实例分析 |
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| 引用本文： | 王思颖,彭六保,曾小慧,欧阳丽辉. Markov模型应用于药物经济学中效用值的计算及实例分析[J]. 中国药房, 2012, 0(18): 1653-1656 |
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| 作者姓名： | 王思颖 彭六保 曾小慧 欧阳丽辉 |
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| 作者单位： | [1]中南大学湘雅二医院药学部,长沙410011 [2]中南大学湘雅医学院药学院,长沙410013 |
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| 基金项目： | 国家自然科学基金项目（81173028） |
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| 摘 要： | 目的:阐述Markov模型基本概念和基本分析方法,为Markov模型在药物经济学中计算效用值的应用提供方法学参考。方法:参考国内、外相关文献及专著,结合具体实例对Markov模型在药物经济学中的运用进行阐述。结果与结论:Markov模型能较好地模拟慢性疾病的发展过程,特别适用于对临床干预远期效果的决策评价。
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| 关 键 词： | Markov模型 药物经济学 蒙特卡罗模拟 敏感度分析 健康效用 |
Application of Markov Model in the Calculation of Utility Value of Pharmacoeconomics and Case Study |
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| Affiliation: | WANG Si-ying,PENG Liu-bao,ZENG Xiao-hui,OUYANG Li-hui(Dept. of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha 410011, China) WANG Si-ying,PENG Liu-bao,ZENG Xiao-hui,OUYANG Li-hui(College of Pharmacy, Xiangya Medical School of Central South University, Changsha 410013,China) |
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| Abstract: | OBJECTIVE： To introduce the basic concepts of Markov model and its basic analysis method aimed at providing methodological reference for the application of Markov model in calculation of utility value of pharmacoeconomics. METHODS： Consulting a great deal of literature and information at home and abroad, the application of Markov model in pharmacoeconomics was illustrated on the basis of special example. RESULTSCONCLUSION： Markov model can simulate the process and development of chronic disease, especially for the decision-making evaluation of long-term clinical intervention effects. |
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| Keywords: | Markov model Pharmacoeconomics Monte Carlo simulation Sensitivity analysis Health value |
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