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不同剂量阿托伐他汀对高血压前期合并高脂血症患者血脂及血压的影响
引用本文:江文艳,宋巧凤.不同剂量阿托伐他汀对高血压前期合并高脂血症患者血脂及血压的影响[J].中国药房,2012(16):1519-1520.
作者姓名:江文艳  宋巧凤
作者单位:唐山市人民医院心内科,河北唐山063000
摘    要:目的:探讨不同剂量阿托伐他汀对高血压前期合并高脂血症患者血脂及血压的影响。方法:将体检发现的120例高血压前期合并高血脂患者随机均分为低剂量组、常规剂量组和对照组,并进行12周不同剂量阿托伐他汀药物干预性治疗。观察3组患者血脂及血压的变化及各组不良反应。结果:在改善血脂方面,常规剂量组优于低剂量组及对照组(P<0.05),低剂量组优于对照组(P<0.05)。在降低血压方面,常规剂量组优于低剂量组及对照组(P<0.05);低剂量组血压较对照组略有下降,但2组比较差异无统计学意义(P>0.05)。3组均未见明显不良反应。结论:常规剂量阿托伐他汀在有效降脂的同时,可进一步降低患者血压,且安全性较好。

关 键 词:高血压前期  血脂  血压  阿托伐他汀

Effect of Different Doses Atorvastatin Therapy on Blood Lipids and Blood Pressure in Patients with Prehypertension and Hyperlipidemia
JIANG Wen-yan,SONG Qiao-feng.Effect of Different Doses Atorvastatin Therapy on Blood Lipids and Blood Pressure in Patients with Prehypertension and Hyperlipidemia[J].China Pharmacy,2012(16):1519-1520.
Authors:JIANG Wen-yan  SONG Qiao-feng
Institution:(Dept.of Cardiology,Tangshan Municipal People's Hospital of Hebei Province,Hebei Tangshan 063000,China)
Abstract:OBJECTIVE:To observe the therapeutic effect of different doses of atorvastatin on blood lipids and blood pressure in patients with prehypertension and hyperlipidemia.METHODS:120 patients with prehypertension and hyperlipidemia were enrolled into the study,and were randomly divided into low dose treatment group,standard dose treatment group and control group.The treatment group was treated with atorvastatin and their blood pressure and lipid levels were checked after 12 weeks and to compared with the control group.RESULTS:The effect of lipid-lowering in received atorvastatin group was better than no receive(P 0.05),standard-dose treatment group was better than low dose treatment group(P0.05).Blood pressure were significantly decreased in standard dose treatment group than low dose treatment group and control group(P0.05);Blood pressure were slight decreased in low dose treatment group than control group(P0.05).No serious adverse drug reaction was found in 3 groups.CONCLUSIONS:Intervention treatment with standard dose atorvastatin is one of the effective measures to decreased blood pressure in patients with prehypertension.
Keywords:Prehypertension  Serum lipids  Blood pressure  Atorvastatin
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