CD11c identifies a subset of murine liver natural killer cells that responds to adenoviral hepatitis |
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Authors: | Burt Bryan M Plitas George Stableford Jennifer A Nguyen Hoang M Bamboat Zubin M Pillarisetty Venu G DeMatteo Ronald P |
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Institution: | Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. |
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Abstract: | The liver contains a unique repertoire of immune cells and a particular abundance of NK cells. We have found that CD11c defines a distinct subset of NK cells (NK1.1(+)CD3(-)) in the murine liver whose function was currently unknown. In na?ve animals, CD11c(+) liver NK cells displayed an activated phenotype and possessed enhanced effector functions when compared with CD11c(-) liver NK cells. During the innate response to adenovirus infection, CD11c(+) NK cells were the more common IFN-gamma-producing NK cells in the liver, demonstrated enhanced lytic capability, and gained a modest degree of APC function. The mechanism of IFN-gamma production in vivo depended on TLR9 ligation as well as IL-12 and -18. Taken together, our findings demonstrate that CD11c(+) NK cells are a unique subset of NK cells in the murine liver that contribute to the defense against adenoviral hepatitis. |
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