改水降氟10年后儿童氟负荷及氟效应指标的调查分析

目的：为评价改水降氟对地方性氟中毒的防治效果。方法：检测分析了病区组、改水病区晨病区组８－１２岁儿童的尿氟和氟毒性效应指标。结果：尿氟均值病区组明显高于改水病区非病区组；尿羟脯氨酸（ＨＯＰ）排泄量均值病区组亦明显高于改水病区组和非病区组改水病区组８－１２岁儿童氟斑牙患病率由１０年前的８２．４％降至６．４５％，明显低于病区组。斑釉齿指数呈依次递减趋势，病区组、改水病区组、非病区组分别为０．７３、０．

A STUDY OF INDICES OF CHILDREN S BODY FLUORINE LOAD TOXIC EFFECTING AFTER TEN YEARS OF DEFLUORIDE OF DRINKING WATER

To assess the effects of defluoride of drinking water. Methods:The urine fluorine and indices of fluoride toxic offecting were determined for three groups of children which were 8 - 12 year old. The three groups were nondefluoride group,defluoride group and non - epidemic area group. Results: The means of urine fluorine of non - defluoride group was much higher then that of defluoride (P < 0.01) and non - epidemic area group( P < 0.01) . The mean of urine hydroxyproline ( HOP) was much higher than that of defluoride group( P < 0.01) and non - epidemic area group ( P < 0.01). After ten years of defluoride of drinking water,the rate of dental fluorosis dropped from 82.4%to 6.45% .The rate 6.45% was much lower than that of non - defluoride group ( P < 0.01) . The dental fluorosis indices of non - defluoride group, defluoride group and non-epidemic area group were decrasing progressively,namely 0.73,0.03.,0.026. In the non-defluoride group the mean of activity of urine creatine phosphokinase(CPK) was much higher than that in defluoride group ( P < 0.01) and non - epidemic area group (P<0.01) .Between the defluoride group and non- epidemic area group,the indices mentioned above were no significantly defference ( P > 0.05) . Conclusion; After defluoride of drinking watwr, the body fluoride load come down and indices of fluoride toxic effecting be improved,because of the decresing of levels of exposure to fluorine.