Intrinsic regulation of locus coeruleus neurons: electrophysiological evidence indicating a predominant role for autoinhibition

Locus coeruleus neurons were antidromically activated and the resulting post-stimulation inhibition was compared to the interspike interval and examined for its dependency on antidromic invasion and stimulus intensity. The post-stimulation inhibition seen in these cells following antidromic activation approximated the interspike interval, was critically dependent on the antidromic invasion of the cell inder study and was only weakly dependent on stimulus intensity. These results suggest that the post-stimulation inhibition following antidromic activation in the locus coeruleus is mediated principally by autoinhibition and not by hypothesized local inhibitory interactions between locus coeruleus neurons.