97例小儿急性淋巴细胞性白血病临床分析

本文对我院儿科6年来收治的97例小儿急性淋巴细胞白血病（ALL）进行临床总结和分析，初治57例，复治40。初治组中43例采用VDLP方案进行诱导缓解，完全缓解（CR）率为100％，复发率为6．9％（3／43），2例为骨髓复发，l例为睾丸白血病复发，无中枢神经系统复发。未采用VDLP方案诱导缓解的另14例初治病人CR率为75％。复治组中VDLP再诱导缓解的CR率为69．2％。非VDLP再诱导缓解的CR率为46．7％。本资料表明采用VDLP是提高CR率的关键，病初白细胞计数和肝脾肿大程度是诱导缓解的影响因素，CR所需时间长短与预后有明显关系，治疗过程中积极处理合并症是提高生存率的重要因素，本资料提示是否近年来ALL－L2有增多趋势，有待进一步观察。

THE CLINICAL ANALYSIS OF 97 CASES OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

This paper reports 97 cases of childhood acute lymphoblastic leukemia hospitalized inBeijing Shijingshan Hospital during the past 6 years (1991. 4-1997. 3). The initial symptomsand main clinical manifestations, the distribution of the clinical subtypes, the response tochemotherapy and survival conditions of the patients were analyzed briefly. These data suggested that L2 type of ALL has a tendency towards increasing recently. Factors influencingCR rate were initial WBC count and hepatosplenomegaly. The time enternal to reach CR wassignificantly prognostic; Treatment for complications was crucial to increase survival rate.(Original article on page 147)