血栓通与生脉注射液联合治疗老年冠心病的临床探讨

为观察血栓通和生脉注射液（ 简称生脉液） 治疗老年冠心病的临床疗效，将５０ 例老年冠心病心绞痛患者，随机分为血栓通与生脉液静脉点滴作治疗组，一般治疗为对照组，进行对比观察。结果显示：血栓通与生脉液治疗组，心绞痛症状改善有效率为９０ ％ ，静息心电图改善有效率为８６ ％ 。心肌耗氧量显著下降。与对照组比较Ｐ ＜ ０ ．０５ ，疗效明显优于一般治疗组，且无毒副作用，尤其适合老年冠心病患者

Clinical results of combined treatment of coronary heart disease from the aged with Chinese herbal drugs: XUE SHUAN TONG and SHENG MAI ZHU SHE YIE

Clinical results of chinese herbal drugs: XUE SHUAN TONG and SHENG MAI ZHU SHE YIE were evaluated for the treatment of coronary heart disease from the aged. 50 aged patients with coronary heart disease were randomly given treatment with XUE SHUAN TONG, SHENG MAI ZHU SHE YIE (the therapeutic group ) and traditional regimen group (the control group). The comparison of the two groups showed that symptom relief of angina pectoris in therapeutic group was 90%, the effective rate of rest ECG improvement was 86%, and oxygen consumption of myocardium decreased significantly, there was statistically different, P<0.05. The combined treatment has good results and no side-effect and is eligible for aged patients with coronary heart disease. Key words angina pectoris; XUE SHUAN TONG; SHENG MAI ZHU SHE YIE; aged; coronary disease r cytochrome P450 2E1(CYP2E1)and/or glutathione S transferase M1(GSTM1)genetic polymorphisms were related to suseptibility to gastric cancer.Genotyping of CYP2E1 and GSTM1 was performed using the polymerase chain reaction on peripheral white blood cell DNA from 91 patients with gastric cancer and 94 controls in a case control study.The results showed that GSTM1 null genotype significantly increased the risk of developing risk of gastric cancer.Persons who carrided the C1/C2 genotpes of CYP2E1 and GSTM1 null had a higher risk of gastric cancer than those with the C1/C1 and GSTM1 nonull genotype,(OR=4 58,85%CI=1 54～14 11).The odds ratio of developing gastric cancer for smoking exposure was strikingly increased in individuals carried the C1/C2 or C2/C2 genotype of CYP2E1 and GSTM1 null(OR=20 00,5%CI=3 69～131 61).These results suggested that CYP2E1 and GSTM1 polymophisms are likely to be associated with gastric cancer susceptibility.