肿瘤相关性低磷抗D骨软化症的外科干预治疗

目的观察分析采用外科手术方法治疗肿瘤相关性低磷抗D骨软化症的早期疗效及此类肿瘤的外科学特点.方法从2004年2月至2005年3月,对7例诊断为肿瘤相关性低磷抗D骨软化症的患者进行手术治疗,完整切除软组织肿瘤5例,骨肿瘤2例.术后平均随访4个月（2周～12月）.结果6例患者术后临床症状明显改善,血磷恢复正常,1例未见明显改善.结论肿瘤低磷抗D骨软化症是一种罕见病例,5例软组织肿瘤临床症状少,常规体检不易发现;2例骨肿瘤在X线片上仅表现为骨密度增高区,无明显溶骨及破坏,易被误诊.一经确诊,手术治疗效果良好.

Surgical treatment of tumor-induced osteomalacia

Objective To observe and analyze the early therapeutic effects of treating the tumor-induced vitamin-D resistant hypo-phosphate osteomalacia by surgical intervention and surgical characters of this kind of tumor.Methods Seven patients with the diagnosis of tumor-induced vitamin-D resistant hypo-phosphate osteomalacia received complete resection operations of tumors from February 2004 to March 2005,with 5 cases of soft connective tissue tumor and 2 of bone tumor.The follow-up period ranged from 2 weeks to 12 months (mean,4 months).Results Six patients improved their symptoms dramatically after operation,with serum phosphate levels restore to normal.One patient has no significant mprovement. Conclusions Tumor-induced vitamin-D resistant hypo-phosphate osteomalacia is a kind of rare disease.Five patients with soft connective tissue tumor have few symptoms,hard to be found by physical examination.X-ray films of two patients with bone tumor show increased density of bone,without obvious osteolysis and bone destructions,therefore it is easy to misdiagnose.Once confirmed,Surgical treatment is necessary,and can achieve a good effect.