Dysregulation of hypothalamic-pituitary-adrenal axis function in depressed alcoholic patients |
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Authors: | S D Targum D E Wheadon C T Chastek W J McCabe M T Advani |
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Affiliation: | The Psychiatric Institute of Washington, Washington, DC, U.S.A. |
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Abstract: | Hypothalamic-pituitary-adrenal (HPA) axis function was examined in 28 hospitalized, withdrawing alcoholic patients. Fourteen patients met DSM-III criteria for Major Depressive Disorder. Elevated 8 a.m. basal cortisols were noted in 7 depressed alcoholic patients (50%) and no non-depressed alcoholics (P less than 0.01). Escape from dexamethasone suppression was noted in 9 depressed alcoholics (64%) and no non-depressed alcoholics (P less than 0.005). The measurement of HPA axis function may be a useful marker for endogenous depression in an alcoholic population. |
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Keywords: | Address all reprint requests to Dr. Targum at 2141 K Street N.W. Suit 704 Washington DC 20037 U.S.A. |
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