| 沙坦类药物代谢酶CYP2C9和受体AT1基因的遗传多态性在高血压患者中的分布特征 |
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| 引用本文： | 杨天伦,陈美芳,谢启应. 沙坦类药物代谢酶CYP2C9和受体AT1基因的遗传多态性在高血压患者中的分布特征[J]. 中南药学, 2007, 5(1): 6-9 |
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| 作者姓名： | 杨天伦 陈美芳 谢启应 |
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| 作者单位： | 中南大学湘雅医院心血管内科 长沙410078 |
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| 摘 要： | 目的本研究旨在观察沙坦类药物代谢酶CYP2C9和反应受体AT1的遗传多态性在高血压患者中的分布特征。方法采用聚合酶链式反应-限制性片断长度多态性方法(PCR-RFLP)对高血压患者进行CYP2C9和血管紧张素AT1受体基因型分析。结果对120名高血压患者CYP2C9和血管紧张素AT1受体进行基因型分析,发现高血压人群中CYP2C9*3的1 061位T等位基因和AT1受体突变1 166位C等位基因的分布频率分别为2.9%、8.0%,而这2个等位基因在中国正常人群的分布频率分别为1.5%、4.3%。结论高血压人群中CYP2C9*3的1061位T等位基因和AT1受体1 166位C等位基因的频率均高于正常人群。
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| 关 键 词： | 血管紧张素AT1受体 高血压 |
| 文章编号： | 1672-2981（2007）01-0006-04 |
| 修稿时间： | 2006-11-30 |
Genetic polymorphism of sartan drug metabolic enzyme CYP2C9 and angiotensin AT1 receptor in hypertensive patients |
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| YANG Tian-lun,CHEN Mei-fang,XIE Qi-ying. Genetic polymorphism of sartan drug metabolic enzyme CYP2C9 and angiotensin AT1 receptor in hypertensive patients[J]. Central South Pharmacy, 2007, 5(1): 6-9 |
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| Authors: | YANG Tian-lun CHEN Mei-fang XIE Qi-ying |
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| Affiliation: | Department of Cardiovascular Internal Medicine, Xiangya Hospital, Central South University, Changsha 410078 |
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| Abstract: | Objective To investigate the genetic polymorphism of sartan drug metabolic enzyme CYP2C9 and angiotensin AT1 receptor in hypertensive patients.Methods Genotype was analyzed by using Polymerase Chain Reaction-Restrict Fragment Length Polymorphism(PCR-RFLP).Results In 120 primary hypertensive patients,the distributive frequencies of 1 061 T for CYP2C9*3 and 1 166C for AT1 receptor were 2.9% and 8.0%,respectively.In Chinese healthy controls,however,the frequencies were 1.5%,4.3%,respectively.Conclusion Frequencies of 1 061T for CYP2C9*3 and 1 166C for AT1 receptor in hypertensive patients are higher than those in healthy populations. |
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| Keywords: | CYP2C9 |
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