Linkage Studies of SOX13, the ICA12 Autoantigen Gene, in Families with Type 1 Diabetes |
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| Authors: | Anthony Argentaro Beth Wapelhorst Patrick Concannon Vincent R. Harley |
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| Affiliation: | a Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, 3010, Australia;b Virginia Mason Research Centre, Department of Immunology, University of Washington, School of Medicine, Seattle, Washington |
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| Abstract: | SOX13 is a member of the SOX family of transcription factors that encodes the type 1 diabetes autoantigen, ICA12. The SOX13 gene maps at chromosome 1q31.3–32.1 near a region containing a susceptibility locus for type 1 diabetes. SOX13 was assessed as a candidate susceptibility gene. Analysis of the SOX13 gene identified a number of single nucleotide polymorphisms and a polymorphic CA dinucleotide repeat. Linkage and association studies indicate that SOX13 is unlikely to make a substantial contribution to type 1 diabetes susceptibility. |
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| Keywords: | IDDM SOX13 ICA12 polymorphisms SRY HMG box linkage diabetes |
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