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| 酸枣仁总黄酮在大鼠尿液和粪便中的代谢与排泄 | |
| 引用本文： | 张 雷,向 诚,王 邠,赵玉英,张庆英.酸枣仁总黄酮在大鼠尿液和粪便中的代谢与排泄[J].中国中药杂志,2009,34(3):340-343. |
| 作者姓名： | 张 雷 向 诚 王 邠 赵玉英 张庆英 |
| 作者单位： | 北京大学,医学部,药学院,天然药物学系,北京,100191 |
| 基金项目： | 国家自然科学基金,长江学者和创新团队计划项目 |
| 摘 要： | 目的:研究酸枣仁总黄酮在大鼠尿液和粪便中的代谢与排泄.方法:将SD大鼠灌胃酸枣仁总黄酮提取物后,于不同时间收集尿液和粪便.经大孔吸附树脂处理尿液和粪便,采用高效液相色谱(HPLC)和高效液相色谱-质谱联用(LC-MS~n)法检测尿液和粪便中的原型药和代谢产物.结果:在尿液和粪便中均检测到总黄酮中的主要化合物酸枣仁黄酮碳苷和6'-阿魏酰酸枣仁黄酮碳苷,并发现一个主要代谢产物酸枣仁黄酮次级碳苷(M_1).结论:酸枣仁总黄酮在大鼠尿液和粪便中主要以原型药酸枣仁黄酮碳苷和6'阿魏酰酸枣仁黄酮碳苷的形式排出,少量以代谢产物的形式如酸枣仁黄酮次级碳苷排泄. |
| 关 键 词： | 酸枣仁 酸枣仁总黄酮 酸枣仁黄酮碳苷 6'-阿魏酰酸枣仁黄酮碳苷 高效液相色谱 高效液相色谱-质谱联用 |
| 收稿时间： | 1/1/1900 12:00:00 AM |
| 修稿时间： | 1/1/1900 12:00:00 AM |
Metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces |
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| ZHANG Lei,XIANG Cheng,WANG Bin,ZHAO Yuying,ZHANG Qingying.Metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces [J].China Journal of Chinese Materia Medica,2009,34(3):340-343. |
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| Authors: | ZHANG Lei XIANG Cheng WANG Bin ZHAO Yuying ZHANG Qingying |
| Institution: | Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Centre, Beijing 100191, China) |
| Abstract: | Objective: To study the metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces. Method: The urine and feces of rats were collected at different times after orally administration of total flavonoids from Semen Ziziphi Spinosae, disposed by HP-20 macroporous resin, and then detected by both HPLC and LC-MSn methods. Result: Two main proto-drugs, spinosin and 6¢¢¢-feruloylspinosin, along with a metabolite, swertish (M1), are detected in both urine and feces of rat. Conclusion: Flavonoids of Semen Ziziphi Spinosae are excreted in urine and feces mainly in form of proto-drug, while little in form of metabolites, such as swertish. |
| Keywords: | Semen Ziziphi Spinosae total flavonoids of Semen Ziziphi Spinosae spinosin 6¢ ¢ ¢ -feruloylspinosin HPLC LC-MSn |
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