关注巨噬细胞在慢性低度炎症性疾病中的作用

已知巨噬细胞在先天免疫系统中发挥着重要的防御作用.近年来,随着慢性低度炎症性疾病概念的提出及深入研究,有关巨噬细胞活化平衡及其在慢性低度炎症性疾病,如肥胖、2型糖尿病、动脉粥样硬化和非酒精性脂肪性肝病等疾病中的致炎作用也逐渐成为当前研究的热点.本文主要阐述了巨噬细胞在这类疾病发生及发展中的重要作用.

Abstract：

It is well known that the macrophages play an important defensive role in the innate immune system. During recent years, with the introduction of the concept of chronic low-grade inflammatory diseases and their further intensive study, the activation and balance of macrophage, as well as its inflammatory effects in chronic lowgrade inflammatory diseases, such as obesity, type 2 diabetes, atherosclerosis, and non-alcoholic fatty liver, are gradually becoming a hot topic of current research. The present article mainly gives an overview of the important role played by macrophages in the inflammatory effects in these diseases.

Pay more attention to the role of macrophages in chronic low-grade inflammatory diseases

It is well known that the macrophages play an important defensive role in the innate immune system. During recent years, with the introduction of the concept of chronic low-grade inflammatory diseases and their further intensive study, the activation and balance of macrophage, as well as its inflammatory effects in chronic lowgrade inflammatory diseases, such as obesity, type 2 diabetes, atherosclerosis, and non-alcoholic fatty liver, are gradually becoming a hot topic of current research. The present article mainly gives an overview of the important role played by macrophages in the inflammatory effects in these diseases.