| 内源分泌型晚期糖化终末产物受体与2型糖尿病颈动脉内膜中层厚度相关 |
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| 引用本文： | 林夏鸿,陈晓毓,李希圣,林晖莉,黄子扬,周竟雄,梁波,林如海,吴晓鸿. 内源分泌型晚期糖化终末产物受体与2型糖尿病颈动脉内膜中层厚度相关[J]. 中华内分泌代谢杂志, 2011, 27(4). DOI: 10.3760/cma.j.issn.1000-6699.2011.04.013 |
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| 作者姓名： | 林夏鸿 陈晓毓 李希圣 林晖莉 黄子扬 周竟雄 梁波 林如海 吴晓鸿 |
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| 作者单位： | 1. 福建医科大学附属第二医院内分泌科,泉州,362000
2. 福建医科大学附属第二医院心血管内科,泉州,362000 |
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| 基金项目： | 福建省泉州市技术研究与开发项目基金 |
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| 摘 要： | 测定78例2型糖尿病患者颈动脉内膜中层厚度(CIMT).CIMT正常组血浆内源分泌型晚期糖化终末产物受体(esRAGE)高于CIMT增厚组[(0.257 3±0.1656对0.155 4±0.0701)峭/L,P<0.01].esRAGE与CIMT负相关r=-0.247,P<0.05).Logistic回归分析显示CIMT与esRAGE和高密度脂蛋白胆固醇负相关,与年龄正相关.Abstract：The carotid initima-media thickness(CIMT)in 78 cases of type 2 diabetic patients was measured.The level of plasma endogenous secretion receptor for advanced glycation end-products(esRAGE)in patients with normal CIMT was higher than those with chickened CIMT[(0.257 3±0.165 6 vs 0.155 4±0.0701)μg/L,P<0.01].esRAGE was negatively associated with CIMT(r=-0.247,P<0.05).Logistic regression analysis showed that CIMT was negatively associated with esRAGE and hish density lipoprotein cholesterol,but was positively associated with age.
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| 关 键 词： | 糖尿病 内源分泌型晚期糖化终末产物受体 颈动脉内膜中层厚度 动脉硬化 |
The level of endogenous secretory receptor for advanced glycation end-products in type 2 diabetes patients is associated with carotid intima-media thickness |
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| LIN Xia-hong,CHEN Xiao-yu,LI Xi-sheng,LIN Hui-li,HUANG Zi-yang,ZHOU Jing-xiong,HANG Bo,LIN Ru-hai,WU Xiao-hong. The level of endogenous secretory receptor for advanced glycation end-products in type 2 diabetes patients is associated with carotid intima-media thickness[J]. Chinese Journal of Endocrinology and Metabolism, 2011, 27(4). DOI: 10.3760/cma.j.issn.1000-6699.2011.04.013 |
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| Authors: | LIN Xia-hong CHEN Xiao-yu LI Xi-sheng LIN Hui-li HUANG Zi-yang ZHOU Jing-xiong HANG Bo LIN Ru-hai WU Xiao-hong |
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| Abstract: | The carotid initima-media thickness(CIMT)in 78 cases of type 2 diabetic patients was measured.The level of plasma endogenous secretion receptor for advanced glycation end-products(esRAGE)in patients with normal CIMT was higher than those with chickened CIMT[(0.257 3±0.165 6 vs 0.155 4±0.0701)μg/L,P<0.01].esRAGE was negatively associated with CIMT(r=-0.247,P<0.05).Logistic regression analysis showed that CIMT was negatively associated with esRAGE and hish density lipoprotein cholesterol,but was positively associated with age. |
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| Keywords: | Diabetes mellitus Endogenous secretion receptor for advanced glycation end-products Carotid intima-media thickness Arteriosclerosis |
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