| 2型糖尿病下肢神经病变心率变异性频域参数的昼夜节律 |
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| 引用本文： | 徐蔷,陈莉明,单春艳.2型糖尿病下肢神经病变心率变异性频域参数的昼夜节律[J].中华内分泌代谢杂志,2011,27(2). |
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| 作者姓名： | 徐蔷 陈莉明 单春艳 |
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| 作者单位： | 卫生部及天津市激素与发育重点实验室,天津医科大学代谢病医院,300070 |
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| 摘 要： | 采用24 h动态心电图检测58例2型糖尿病伴下肢神经病变组、59例2型糖尿病不伴下肢神经病变组(非下肢神经病变组)和50例对照组的心率变异性,比较其频域参数的水平及昼夜间的变化.结果 显示非下肢神经病变组、下肢神经病变组较对照组频域指标减小,平均心率增加;昼夜间比较在对照组差异有统计学意义,在非下肢神经病变组昼夜节律发生改变,在下肢神经病变组昼夜节律消失.提示糖尿病不伴和伴下肢神经病变均存在自主神经功能受损,后者受损更明显.Abstract：Heart rate variability(HRV)analysis and its circadian rhythm(CR)were determined in 58patients with type 2 diabetes mellitus with lower extremity neuropathy(diabetic neuropathy group), 59 patients with type 2 diabetes mellitus without lower extremity neuropathy(diabetes group), and 50 healthy controls according to 24-hour Holter recording. Frequency domain parameters of HRV were significantly decreased in both diabetes groups. Frequency domain parameter of HRV in healthy controls,and daytime/nighttime difference were statistically significant. CR of HRV was changed in diabetes group and disappeared in diabetic neuropathy group. Impaired and seriously impaired autonomic nervous function developed in type 2 diabetes mellitus without and with lower extremity neuropathy respectively.
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| 关 键 词： | 糖尿病 2型 糖尿病自主神经病变 心率变异性 昼夜节律 |
Frequency domain parameter of heart rate variability and its circadian rhythm in type 2 diabetes with lower extremity neuropathy |
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| XU Qiang,CHEN Li-ming,SHAN Chun-yan.Frequency domain parameter of heart rate variability and its circadian rhythm in type 2 diabetes with lower extremity neuropathy[J].Chinese Journal of Endocrinology and Metabolism,2011,27(2). |
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| Authors: | XU Qiang CHEN Li-ming SHAN Chun-yan |
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| Abstract: | Heart rate variability(HRV)analysis and its circadian rhythm(CR)were determined in 58patients with type 2 diabetes mellitus with lower extremity neuropathy(diabetic neuropathy group), 59 patients with type 2 diabetes mellitus without lower extremity neuropathy(diabetes group), and 50 healthy controls according to 24-hour Holter recording. Frequency domain parameters of HRV were significantly decreased in both diabetes groups. Frequency domain parameter of HRV in healthy controls,and daytime/nighttime difference were statistically significant. CR of HRV was changed in diabetes group and disappeared in diabetic neuropathy group. Impaired and seriously impaired autonomic nervous function developed in type 2 diabetes mellitus without and with lower extremity neuropathy respectively. |
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| Keywords: | Diabetes mellitus type 2 Diabetic autonomic neuropathy Heart rate variability Circadian rhythm |
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