骨代谢调控的垂体-骨轴机制

近年来,垂体激素包括促甲状腺激素、FSH、促肾上腺皮质激素以及催产素等,相继被发现对骨代谢具有直接的调控作用.这一发现打破了垂体激素是通过作用于靶内分泌腺间接对骨代谢进行调节的传统观念,从而提出了骨代谢调控的垂体-骨轴(pituitary-bone axis)新概念.这些突破性研究进展使人们对垂体激素的功能有了全新的了解,并且对甲亢、绝经、妊娠等引起的骨质疏松症以及糖皮质激素引起的骨坏死的发病机制有了更深的认识,为相关骨代谢疾病的防治以及新药研发提供了新的科学思路和理论基础.

Abstract：

Recent studies have shown that pituitary hormones, including thyroid stimulating hormone (TSH), follicle stimulating hormone(FSH), adrenocorticotropic hormone(ACTH), and oxytocin(OT)may actually bypass their target endocrine organs and affect the skeleton directly. Therefore, a new conception, pituitary-bone axis is proposed. This breakthrough sheds a new light on the function of pituitary hormones and the pathogenesis of osteoporosis associated with hyperthyroidism, menopause or pregnancy, and even osteonecrosis after using glucocorticoids. In addition, it is conducive to give the reference guidance for clinical treatment of metabolic bone diseases and new drug development.

The pituitary-bone axis in bone metabolism

Recent studies have shown that pituitary hormones, including thyroid stimulating hormone (TSH), follicle stimulating hormone(FSH), adrenocorticotropic hormone(ACTH), and oxytocin(OT)may actually bypass their target endocrine organs and affect the skeleton directly. Therefore, a new conception, pituitary-bone axis is proposed. This breakthrough sheds a new light on the function of pituitary hormones and the pathogenesis of osteoporosis associated with hyperthyroidism, menopause or pregnancy, and even osteonecrosis after using glucocorticoids. In addition, it is conducive to give the reference guidance for clinical treatment of metabolic bone diseases and new drug development.