| 阴茎勃起功能障碍的基因治疗进展 |
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| 引用本文： | 刘继红,李明超.阴茎勃起功能障碍的基因治疗进展[J].中华男科学杂志,2011,17(2):99-103. |
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| 作者姓名： | 刘继红 李明超 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院泌尿外科,湖北,武汉,430030 |
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| 摘 要： | 50～70岁男性中50%以上患有勃起功能障碍(ED),40岁的男性中有40%的患有不同程度的ED,全球范围内ED患者已超过1亿人,ED已成为困扰全球男性的重要疾病之一。在过去的20年里,对于ED发生机制及治疗有了很大的进展,现有的PDE5抑制剂对大部分ED患者疗效较好,但是对糖尿病性ED、前列腺癌根治术后ED及严重的心血管病变导致的ED疗效欠佳。人们正在寻找更好的治疗ED的方法——基因治疗。本文总结了近年来临床前期基因治疗ED的新进展,即糖尿病ED、老年性ED、神经损伤性ED及血管病变导致的ED的基因治疗。
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| 关 键 词： | 勃起功能障碍 基因治疗 进展 |
Gene therapy for erectile dysfunction:An update |
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| LIU Ji-hong,LI Ming-chao.Gene therapy for erectile dysfunction:An update[J].National Journal of Andrology,2011,17(2):99-103. |
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| Authors: | LIU Ji-hong LI Ming-chao |
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| Institution: | LIU Ji-hong,LI Ming-chao Department of Urology,Tongji Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China |
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| Abstract: | Erectile dysfunction (ED) affects over 50% of men between 50 and 70 years of age, and 40% of men aged about 40 years suffer from some form of erectile dysfunction. ED, with more than 100 million sufferers in the world, has become a serious disease besetting the male patients. Great strides have been achieved in understanding the pathogenesis and potential therapeutics of ED over the past two decades. The development of phosphodiesterase type 5 (PDE5) inhibitors has revolutionized the treatment of ED, but th... |
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| Keywords: | erectile dysfunction gene therapy progress |
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