Therapeutic Interventions for Frail Elderly Patients: Part I. Published Randomized Trials |
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| Authors: | Lior Bibas Michael Levi Melissa Bendayan Louis Mullie Daniel E. Forman Jonathan Afilalo |
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| Affiliation: | 1. Department of Medicine, McGill University, Montreal, Canada;2. Division of Cardiology, McGill University, Montreal, Canada;3. Department of Physiology, McGill University, Montreal, Canada;4. Section of Geriatric Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States;5. Geratric Research Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, United States;6. Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital, Montreal, Canada |
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| Abstract: | The body of literature for frailty as a prognostic marker continues to grow, yet the evidence for frailty as a therapeutic target is less well defined. In the setting of cardiovascular disease, the prevalence of frailty is elevated and its impact on mortality and major morbidity is substantial. Therapeutic interventions aimed at improving frailty may impart gains in functional status and survival. Randomized clinical trials that tested one or more therapeutic interventions in a population of frail older adults were reviewed. The interventions studied were exercise training in 13 trials, nutritional supplementation in 4 trials, combined exercise plus nutritional supplementation in 7 trials, pharmaceutical agents in 8 trials, multi-dimensional programs in 5 trials, and home-based services in 1 trial. The main findings of these trials are explored along with a discussion of their relative merits and limitations. |
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| Keywords: | Frailty Sarcopenia Randomized clinical trials |
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