慢性心力衰竭时尿酸水平的变化及对预后的影响

目的:研究慢性心力衰竭(CHF)患者尿酸水平对其预后的影响。方法:观察142例初次入院的CHF患者的血尿酸与心功能的变化;并进行随访1年。对比在随访期间高尿酸血症组和非高尿酸血症组患者死亡、再住院次数、再住院总时间。结果:心衰患者高尿酸血症发生率36.6%,随着心功能恶化,尿酸水平逐渐增加,高尿酸血症发生率逐渐升高(P均<0.05);在随访期间,高尿酸血症组和非高尿酸血症组患者相比,死亡率、平均住院次数和平均住院时间明显增加(P均<0.05)。结论:高尿酸血症在CHF患者中常见;对于CHF患者,高尿酸血症是预后不良因素之一。

Change of blood uric acid concentration and its influence on prognosis in patients with congestive heart failure

Objective:To study the change of blood uric acid concentration and its influence on prognosis in patients with congestive heart failure(CHF).Methods:The blood uric acid concentration and heart function were observed in 142 CHF patients.The mortality,number and total days of rehospitalization were compared between hyperuricacidemia group and no-hyperuricacidemia group in one year followed.Results:The morbidity of hyperuricacidemia group was 36.6% in CHF patients.When NYHA heart function degree increased the level of blood uric acid and morbidity of hyperuricacidemia gradually increased(P<0.05 all).The mortality,number and total days of rehospitalization increased in hyperuricacidemia group compared with that of no-hyperuricacidemia group(P<0.05 all)Conclusion:Hyperuricacidemia is considerable and is a factor of unfavorable prognosis in CHF patients.