Immunomodulatory activity of polysaccharide from Acanthopanax obovatus roots. |
| |
Authors: | J Z Wang X J Mao H Ito K Shimura |
| |
Institution: | Department of Pharmacology, Mie University School of Medicine, Japan. |
| |
Abstract: | The effects of the Acanthopanax obovatus polysaccharide (AOPS) as well as its combination with cyclophosphamide (CY) or prednisolone on immune responses were investigated in mice. AOPS (250 mg/kg i.p. x 5) increased the spleen weight and the number of spleen cells, and augmented the phagocytosis of peritoneal macrophages both in normal mice and in immunosuppressed mice. In a haemagglutinin assay AOPS increased the production of specific antibodies and antagonized the suppressive effect of CY. AOPS not only enhanced the degree of in vitro spleen cell-mediated red blood cells (SRBC) hemolysis (quantitative hemolysis of SRBC) but also restored the suppressive effect of CY completely. From these results, AOPS was shown to have an enhancing and a modulating activity on immune responses. |
| |
Keywords: | |
|
|