Regeneration of respiratory epithelia in the rat after free grafting |
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Authors: | F. Bootz G. Reuter |
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Affiliation: | (1) Department of Otorhinolaryngology, University of Tubingen, Silcherstrasse 5, W-7400 Tübingen, Federal Republic of Germany |
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Abstract: | Summary Following free grafting of septal mucosa from the rat to the rectus abdominis muscle, the mucosal membrane was found to degenerate into a flat squamous epithelium with loss of the majority of differentiated epithelial cells. Both the goblet cells and ciliated cells regenerated from stem cells, which appear in large numbers 2 days after trasnsplantation. Microvilli were found initially on the surfaces of developing ciliated cells and were replaced 21 days post-grafting by cilia. The number of goblet cells during regeneration at first exceeded that of the ciliated cells, but decreased with the passage of time. After 4 months there were more ciliated cells, with the respiratory epithelium now appearing no different than the initially transplanted nasal mucosa.Correspondence to: F. Bootz |
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Keywords: | Respiratory epithelium Free grafting Mucosal regeneration Reconstructive head and neck surgery |
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