| 淫羊藿苷固体脂质纳米粒的大鼠体内药动学研究 |
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| 引用本文： | 刘丛丛,张琦,孙学惠,郭涛. 淫羊藿苷固体脂质纳米粒的大鼠体内药动学研究[J]. 中国药物应用与监测, 2013, 0(4): 203-206 |
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| 作者姓名： | 刘丛丛 张琦 孙学惠 郭涛 |
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| 作者单位： | 1. 沈阳军区总医院药剂科，辽宁 沈阳 110016; 徐州医药高等职业学校，江苏 徐州221116
2. 沈阳军区总医院药剂科,辽宁 沈阳,110016 |
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| 摘 要： | 目的:考察淫羊藿苷固体脂质纳米粒(ICA-SLN)在大鼠体内的药动学行为,以及利用固体脂质纳米粒技术提高ICA口服生物利用度的可行性。方法:对2组大鼠分别灌胃ICA混悬液和ICA-SLN混悬液后,采用HPLC-MS/MS法测定大鼠体内ICA的血药浓度,比较ICA混悬液和ICA-SLN混悬液在大鼠体内的吸收情况。结果:ICA在体内的药-时曲线呈现双峰,tmax为1 h,t1/2为3 h。载药纳米粒组与对照组的AUC0-∞分别为(233.6±71.2)ng.h.mL-1和(107.4±15.7)ng.h.mL-(1P<0.05)。结论:与单纯口服ICA相比较,ICA-SLN在大鼠体内的生物利用度更高。
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| 关 键 词： | 淫羊藿苷 固体脂质纳米粒 药物代谢动力学 生物利用度 |
Study on pharmacokinetics of icariin loaded solid lipid nanoparticles in rats |
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| LIU Cong-cong , ZHANG Qi , SUN Xue-hui , GUO Tao. Study on pharmacokinetics of icariin loaded solid lipid nanoparticles in rats[J]. , 2013, 0(4): 203-206 |
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| Authors: | LIU Cong-cong ZHANG Qi SUN Xue-hui GUO Tao |
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| Affiliation: | LIU Cong-cong, ZHANG Qi, SUN Xue-hui, GUO Zao(1. Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110016, China; 2. Xuzhou Pharmaceutical Vocational College, Xuzhou 221116, China) |
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| Abstract: | Objective： To investigate the pharmacokinetics of icariin （ICA） loaded solid lipid nanoparticles （ICA-SLN） in rats and to evaluate the feasibility of improving ICA＇s oral bioavailability. Methods： Using HPLC-MS/MS to determine the concentration of ICA in rats after oral administration of ICA suspension and ICA-SLN respectively, the pharmacokinetic parameters of two goups were calculated by DAS 2.0 software. Results： There were two peaks in drug concentration-time profile of ICA, tmax was 1 h, t1/2 was 3 h. AUC0-∞ of oral ICA-SLN groups and ICA groups were （233.6 ± 71.2） ng.h.mLl, （107.4 ± 15.7 ） ng-h.mL^-1 respectively （P 〈 0.05）. Conclusion： Compared with ICA, ICA-SLN is a promising delivery system to enhance the bioavailability of ICA in rats. |
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| Keywords: | Icariin (ICA) Solid lipid nanoparticles Pharmacokinetics Bioavailability |
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