On the origin of the osteoclast: The cell surface phenotype of rodent osteoclasts |
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Authors: | Dr M A Horton E F Rimmer A Moore T J Chambers |
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Institution: | (1) Department of Haematology, St. Bartholomew's Hospital Medical College, EC1A 7BE London, U.K.;(2) Department of Histopathology, St. Bartholomew's Hospital Medical College, EC1A 7BE London, U.K. |
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Abstract: | Summary The origin and development of the osteoclast is not well defined; although it is derived from a bone marrow stem cell, it
is not proven whether the osteoclast progenitor comes from the multipotential hemopoietic stem cell or comprises an entirely
separate cell lineage. We have studied the cell lineage relationship of osteoclasts isolated from newborn rodent bone to other
bone marrow cell types, in particular the monocyte-macrophage cell line, by the use of cell surface phenotyping. In studies
in mouse and rat we failed to detect the expression of markers characteristic of mononuclear phagocytes or other bone marrow
cell types, including the hemopoietic tissue restricted common leucocyte antigen (T200). Our findings cast further doubt on
the view that osteoclasts arise by fusion of mononuclear phagocytes in a similar fashion to the formation of multinucleate
inflammatory giant cells. |
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Keywords: | Osteoclast Rodent Macrophage Cell surface antigens |
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