| 花椒毒酚对家兔胸主动脉条收缩的影响 |
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| 引用本文： | 曾靖,连其深,周青,周俐,叶和杨,黄贤华. 花椒毒酚对家兔胸主动脉条收缩的影响[J]. 中药材, 2003, 26(11): 809-811 |
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| 作者姓名： | 曾靖 连其深 周青 周俐 叶和杨 黄贤华 |
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| 作者单位： | 赣南医学院药理教研室,江西 赣州 341000 |
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| 基金项目： | 江西省科技厅科技计划资助项目 (2 0 0 2 10 3 10 0 1) |
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| 摘 要： | 目的 :研究花椒毒酚 (XT)对家兔胸主动脉条的作用及其与Ca2 + 的关系。方法 :采用常规动脉条收缩的实验方法。结果 :XT可使NE、KCl(PD12 值为 3 5 8± 0 0 7)和CaCl2 (PD12 值为 4 12± 0 12 )引起的家兔胸主动脉条量 效收缩曲线右移 ,最大效应降低。与维拉帕米 (Ver)相似 ,是通过钙拮抗来实现的。而XT与Ver拮抗Ca2 + 的方式基本相似 ,可选择性地阻断电压依赖性 (VDC)Ca2 + 通道 ,而对受体控制性 (ROC)Ca2 + 通道无影响。结论 :XT具有选择性阻断电压依赖性Ca2 + 通道。
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| 关 键 词： | 花椒毒酚 家兔 胸主动脉条收缩 钙通道阻滞剂 电压依赖性 |
| 修稿时间： | 2003-04-04 |
Effect of Xanthnotoxol on Contraction of Rabbit Thoracic Aortic Strips |
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| Zeng Jing,Lian Qishen,Zhou Qing,Zhou Li,Ye Heyang,Huang Xianhua. Effect of Xanthnotoxol on Contraction of Rabbit Thoracic Aortic Strips[J]. Journal of Chinese medicinal materials, 2003, 26(11): 809-811 |
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| Authors: | Zeng Jing Lian Qishen Zhou Qing Zhou Li Ye Heyang Huang Xianhua |
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| Affiliation: | Gannan Medical College, Ganzhou 341000. |
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| Abstract: | OBJECTIVE: To study the effect of xanthnotoxol (XT) on contractility of rabbit thoracic aorta strips and its relationship with Ca2+. METHODS: Routine experimental methods for isolated thoracic aorta strips were adopted. RESULTS: XT and verapamil (Ver) can make the dose-response curve of rabbit thoracic aorta strips induced by NE, KCl, CaCl2 shifed right (the pD'2 of KCl and CaCl2 value was 3.58 +/- 0.07 and 4.12 +/- 0.12) and depressed the maximal responses. Like verapamil (Ver), it is accomplished by calcium antagonism. XT could selectively block the voltage dependence calcium channel (VDC), and have no effect on the receptor operated calcium channel (ROC). CONCLUSION: It suggested XT had selectly blocking effect on voltage dependence calcium channel. |
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| Keywords: | Xanthnotoxol Thoracic aortic strips Calcium channel blockers Voltage dependence calcium channel |
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