辛伐他汀对慢性心力衰竭患者血清对氧磷酶-1及氧化应激水平的影响

目的探讨辛伐他汀对慢性心力衰竭患者血清对氧磷酶-1及氧化应激水平的影响。方法选择慢性心力衰竭、心功能Ⅳ级患者80例，随机分为对照组（40例）和治疗纽（40例），对照组给予常规三联基础疗法，治疗组在对照组治疗基础上给予辛伐他汀20mg，每日1次口服，2组均治疗28d。另选择同期体检正常者30例为正常对照组。观察对氧磷酶-1（PON-1）、总抗氧化物（TAS）及过氧化脂质（LPO）水平变化。结果治疗组和对照组治疗前血清PON-1及TAS较正常对照组明显降低，LPO明显升高，组间比较差异有统计学意义（P〈0．05）；2组治疗后血清PON-1及TAS水平均升高，LPO水平均下降，与本组治疗前比较差异有统计学意义（P〈0．05）；2组治疗后治疗组血清PON-1及TAS升高水平与LPO下降水平均优于对照组，组间比较差异有统计学意义（P〈0．05）。结论辛伐他汀可以提高血清对氧磷酶-l的水平，调节机体的氧化应激水平，改善慢性心力衰竭的预后。

Effect of Simvastatin on serum paraoxonase - 1 and oxidative stress levels in patients with chronic heart failure

Objective To investigate the effect of Simvastatin on serum paraoxonase - 1 and oxidative stress levels in patients with chronic heart failure. Methods 80 chronic heart failure patients with cardiac function grade IV were randomly divided into control group （ n = 40 ） and treatment group （ n = 40）. The control group received of conventional triple basic therapy. Patients in treatment group were treated by Simvastatin, 20 rag, once a day on the basis of treatment of control group. The course was 2 days in two groups. 30 healthy volunteers at the same period were selected as normal control group. Serum paraoxonase - 1 （ PON - 1 ） was measured by spectrophotometry. Total antioxidant status （TAS） was detected by automated analyzer. Lipid peroxide （LPO） was measured by FOX before and after treatment. Results Serum PON - 1 and TAS in treatment group and control group were lower than those in normal control group before treatment （ P 〈 0.05 ）. The level of LPO was higher （ P 〈 0.05 ）. The levels of serum PON - 1 and TAS after treatment were increased as compared with those before treatment in treatment group and con- trol group （ P 〈 0.05 ）. LPO was decreased after treatment （ P 〈 0.05 ）. The improvement of levels of PON - 1 , TAS and LPO in treatment group were superior to those in control group （ P 〈 0.05 ）. Conclusion Simvastatin may increase the level of serum paraoxonase -1, regulate the body＇s oxidative stress level, and improve the prognosis of chronic heart failure.