| c-Cbl、Cbl-b和EGFR在胃癌组织中的表达及其临床意义 |
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| 引用本文： | 董茜,刘云鹏,曲秀娟,侯科佐,李琳琳. c-Cbl、Cbl-b和EGFR在胃癌组织中的表达及其临床意义[J]. 癌症, 2010, 29(1): 59-64 |
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| 作者姓名： | 董茜 刘云鹏 曲秀娟 侯科佐 李琳琳 |
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| 作者单位： | 中国医科大学附属第一医院肿瘤内科;中国医科大学附属盛京医院肿瘤科;辽宁省肿瘤医院肿瘤内科; |
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| 基金项目： | 国家自然科学基金项目(No.30770993)~~ |
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| 摘 要： | 背景与目的:c-Cbl和Cbl-b是CBL(the Casitas B-cell lymphoma)家族的两个重要成员,具有连接体功能及E3泛素连接酶功能,在表皮生长因子受体(epidermal growth factor receptor,EGFR)下调过程中发挥重要作用。本研究旨在探讨c-Cbl、Cbl-b和EGFR在胃癌组织中的表达及其临床意义。方法:将124例胃癌术后标本和16例癌旁正常胃组织制作成组织芯片,应用免疫组化方法检测c-Cbl、Cbl-b和EGFR的表达情况,并分析其与临床及病理因素的关系。结果:124例胃癌中c-Cbl、Cbl-b和EGFR的阳性率分别为71.0%、82.3%和56.5%,均显著高于癌旁正常胃组织(分别为18.0%、25.0%和12.5%,均P<0.01)。c-Cbl表达与浸润深度及病理分期呈正相关(r=0.219,P=0.015和r=0.266,P=0.003);Cbl-b表达与淋巴结转移及病理分期呈正相关(r=0.190,P=0.034和r=0.298,P=0.001);EGFR表达与浸润深度及病理分期呈正相关(r=0.286,P=0.001和r=0.362,P=0....
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| 关 键 词： | c-Cbl Cbl-b 表皮生长因子受体（EGFR） 胃癌 |
Expressions of c-Cbl,Cbl-b,and epidermal growth factor receptor in gastric carcinoma and their clinical significance |
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| Qian Dong,, Yun-Peng Liu, Xiu-Juan Qu, Ke-Zuo Hou , Lin-Lin Li. Expressions of c-Cbl,Cbl-b,and epidermal growth factor receptor in gastric carcinoma and their clinical significance[J]. Chinese journal of cancer, 2010, 29(1): 59-64 |
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| Authors: | Qian Dong Yun-Peng Liu Xiu-Juan Qu Ke-Zuo Hou Lin-Lin Li |
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| Affiliation: | Qian Dong,1,2 Yun-Peng Liu,1 Xiu-Juan Qu,1 Ke-Zuo Hou1 , Lin-Lin Li31.Department of Medical Oncology,The First Affiliated Hospital,China Medical University,Shenyang,110001,Liaoning,P.R.China 2.Department of Oncology,Shengjing Hospital,110004,P.R.China 3.Department of Medical Oncology,Liaoning Province Tumor Hospital,110042,P.R.China |
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| Abstract: | Background and Objective:c-Cbl and Cbl-b are two major members of the Casitas B-lineage lymphoma (Cbl) family,which play important roles in down-regulation of epidermal growth factor receptor (EGFR) by acting as E3 ubiquitin ligases and multi-adaptor proteins.This study was to investigate the expressions of c-Cbl,Cbl-b,and EGFR in gastric carcinoma and their clinical significance.Methods:The expressions of c-Cbl,Cbl-b,and EGFR were detected by immunohistochemistry using tissue microarrays consisting of 124 ... |
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