| 鞘内注射艾司洛尔对福尔马林疼痛大鼠脊髓背角c-fos蛋白表达的影响 |
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| 引用本文： | 陈烨,邹聪华,陈彦青.鞘内注射艾司洛尔对福尔马林疼痛大鼠脊髓背角c-fos蛋白表达的影响[J].临床麻醉学杂志,2011,27(10). |
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| 作者姓名： | 陈烨 邹聪华 陈彦青 |
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| 作者单位： | 福建医科大学省立临床学院(福建省立医院)麻醉科, 福州市,350000 |
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| 摘 要： | 目的探索大鼠鞘内注射艾司洛尔能否抑制福尔马林大鼠脊髓背角c-fos蛋白表达。方法雄性SD大鼠,鞘内置管成功后,随机分为三组(n=8):生理盐水组(N组),艾司洛尔300μg/kg组(E1组),艾司洛尔600μg/kg组(E2组)。在异氟醚麻醉下,鞘内注射上述药物10μl,5 d后,所有大鼠一侧后肢爪掌背侧皮下注射福尔马林(5%,50μl),观察大鼠在Ⅰ相(0~5 min)和Ⅱ相(15~50 min)疼痛行为学变化(包括添足、咬足、抬腿动作等),并进行Dubuisson评分。采用免疫组织化学方法检测脊髓背角c-fos蛋白表达。结果与N组比较,E1、E2组大鼠Ⅱ相阶段的疼痛相关行为均有减少,呈量效关系(P<0.05),且E1、E2组L4~5节段脊髓表达的c-fos蛋白均较N组减少(P<0.05)。结论鞘内注射艾司洛尔可减少福尔马林大鼠脊髓背角c-fos蛋白表达。
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| 关 键 词： | 艾司洛尔 福尔马林 疼痛 脊髓 c-fos |
Effects of intrathecal esmolol on spinal c-fos expression in a formalin-induced pain model |
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| CHEN Ye,ZOU Cong-hua,CHEN Yan-qing.Effects of intrathecal esmolol on spinal c-fos expression in a formalin-induced pain model[J].The Journal of Clinical Anesthesiology,2011,27(10). |
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| Authors: | CHEN Ye ZOU Cong-hua CHEN Yan-qing |
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| Institution: | CHEN Ye,ZOU Cong-hua,CHEN Yan-qing.Department of Anesthesiology,The Fujian Provincial Medical College of Fuzhou Medical University,Fuzhou,350000,China |
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| Abstract: | Objective To investigate the effect of intrathecal esmolol on the expression of c-fos in the dorsal horn of spinal cord in a formalin-induced pain model.Methods Twenty-four SD rats were randomly divided into 4 groups with 8 each.Every mouse received intrathecal catheter placement and was infused with saline 10 L(group N),esmolol 300 g/kg(group A),or 600 g/kg(group B),respectively.Pain was induced by 50 L of 5% formalin solution injected into the dorsal surface of the right hind paw.The nociceptive behaviors... |
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| Keywords: | Esmolol Formalin Pain Spinal cord c-fos |
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