Carcinoma Cuniculatum Arising in the Tongue |
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| Authors: | Selvam Thavaraj Alistair Cobb Nicholas Kalavrezos Timothy Beale Donald Murray Walker Amrita Jay |
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| Institution: | (1) Oral Pathology, Department of Clinical and Diagnostic Sciences, King’s College London Dental Institute, Floor 28 Tower Wing, Great Maze Pond, London, SE1 9RT, UK;(2) Head & Neck Centre, University College London Hospitals NHS Foundation Trust, 1st Floor East Wing, 250 Euston Road, London, NW1 2PG, UK;(3) Department of Radiology, University College Hospital, 235 Euston Road, London, NW1 2BU, UK;(4) Department of Histopathology, University College London Hospitals NHS Foundation Trust, Rockefeller Building, University Street, London, WC1E 6JJ, UK |
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| Abstract: | Carcinoma cuniculatum (CC) is a rare, distinct clinico-pathological variant of squamous cell carcinoma (SCC) that is defined
histologically by the characteristic infiltrative pattern of a deep, broad, and complex proliferation of stratified squamous
epithelium with keratin cores and keratin-filled crypts. Herein, we present a case report of CC of the oral tongue and discuss
its diagnosis, management, and outcome, as well as briefly review the world literature. To our knowledge, this is the first
documented case of CC of the tongue to be reported in the English literature. We draw attention to its clinico-pathological
features and highlight that awareness of this entity as a distinct variant of SCC facilitates its correct management. |
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| Keywords: | Carcinoma cuniculatum Verrucous carcinoma Squamous cell carcinoma Tongue |
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