| 氯胺酮对神经病理性痛大鼠海马长时程增强维持的影响 |
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| 引用本文： | 魏辉明,麻伟青,杨云丽,李治贵,王慧明,张承华. 氯胺酮对神经病理性痛大鼠海马长时程增强维持的影响[J]. 临床麻醉学杂志, 2011, 27(10) |
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| 作者姓名： | 魏辉明 麻伟青 杨云丽 李治贵 王慧明 张承华 |
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| 作者单位： | 成都军区昆明总医院麻醉科, 昆明市,650032 |
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| 摘 要： | 目的探讨氯胺酮对神经病理性痛大鼠海马CA1区突触长时程增强(LTP)维持的影响。方法成年雄性Wistar大鼠15只,随机均分为三组:神经病理性痛模型组(NP组)、氯胺酮1组(K1组)、氯胺酮2组(K2组)。采用结扎L4,5左侧脊神经的方法制备大鼠模型,于术前、术后1、2和3周观察大鼠痛行为学及足部形态;于术前、术后1、2和3周测定痛阈;于最后一次痛阈测定结束后3 d记录海马CA1区兴奋性突触后电位(EPSP),以高频刺激(HFS)诱发LTP。K1组于HFS前20 min经腹腔注射氯胺酮25 mg/kg,K2组HFS后60 min腹腔注射氯胺酮25 mg/kg。结果与术前比较,术后三组各时点痛阈降低(P<0.05);与基础值比较,NP组与K2组HFS后各时段EPSP幅值升高(P<0.05),与NP组和K2组比较,K1组HFS后各时段降低(P<0.05)。结论氯胺酮可阻滞神经病理性痛大鼠海马CA1区突触LTP的诱导,但不干扰维持。
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| 关 键 词： | 氯胺酮 神经痛 长时程增强 海马 |
Effect of ketamine on maintenance of synaptic long-term potentiation in hippocampus in rats with neuropathic pain |
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| WEI Hui-ming,MA Wei-qing,YANG Yun-li,et al.. Effect of ketamine on maintenance of synaptic long-term potentiation in hippocampus in rats with neuropathic pain[J]. The Journal of Clinical Anesthesiology, 2011, 27(10) |
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| Authors: | WEI Hui-ming MA Wei-qing YANG Yun-li et al. |
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| Affiliation: | WEI Hui-ming,MA Wei-qing,YANG Yun-li,et al.Department of Anesthesiology,Kunming General Hospital of Chengdu Military Command,Kunming 650032,China |
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| Abstract: | Objective To investigate the effect of ketamine on maintenance of synaptic long-term potentiation(LTP) in hippocampus in rats with neuropathic pain.Methods Fifteen adult male Wistar rats were randomly divided into 3 groups(n=5 each): group neuropathic pain(group NP),group ketamine 1(group K1) and group ketamine 2(group K2).Neuropathic pain was produced by ligation of the left L4,5 spinal nerve.The behaviour of the rats was evaluated.Pain threshold was measured at 1,2 and 3 week after surgery.The excitatory ... |
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| Keywords: | Ketamine Neuralgia Long-term potentiation Hippocampus |
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