| 不同类型多发性硬化的临床及影像学特点 |
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| 引用本文： | 范秉林,李晓峰,李吕力,罗永坚,李燕华,董艳玲.不同类型多发性硬化的临床及影像学特点[J].临床神经病学杂志,2011,24(4). |
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| 作者姓名： | 范秉林 李晓峰 李吕力 罗永坚 李燕华 董艳玲 |
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| 作者单位： | 广西壮族自治区人民医院神经内科,南宁,530021 |
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| 基金项目： | 广西医疗卫生重点科研课题资助(重2010028) |
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| 摘 要： | 目的探讨不同类型多发性硬化(MS)的临床及影像学特点。方法对57例晚发型MS(LOMS)患者和57例早发型MS(YOMS)患者的临床及影像学的资料进行分析和比较。结果 LOMS组首次发病的运动障碍及病程中括约肌功能障碍的出现率明显高于YOMS组(P<0.05～0.01),而首次发病的感觉障碍、视觉障碍,查体发现的运动、视觉和构音障碍、视神经炎及病程中新发运动障碍出现率明显低于YOMS组(P<0.05～0.01)。LOMS组78.9%多为原发进展型,而YOMS组70.2%为复发缓解型,两组间的差异有统计学意义(均P<0.001)。LOMS组脑脊液细胞增高的比率、脑脊液细胞数平均值(17.5%,5×106/L)与YOMS组(35.1%,14×106/L)比较差异具有统计学意义(均P<0.005)。MRI显示,YOMS组小脑病灶出现率(60.0%)明显高于LOMS组(25.0%),而LOMS组脊髓异常的比率(47.4%)明显高于YOMS组(24.6%)(P<0.05～0.01)。急性发作期大剂量糖皮质激素治疗LOMS组显效20例(35.1%),YOMS组为41例(71.9%),两组的差异具有统计学意义(P<0.05...
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| 关 键 词： | 多发性硬化 临床特点 脑脊液 磁共振 |
Clinical and imaging features in different types of multiple sclerosis |
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| Institution: | FAN Bing-lin,LI Xiao-feng,LI Lü-li,et al.Department of Neurology,the People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China |
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| Abstract: | Objective To explore the clinical and imaging features in different types of multiple sclerosis(MS). Methods The clinical date of 57 late-onset multiple sclerosis(LOMS) patients and 57 young-onset MS(YOMS) patients were analyzed and compared. Results The rates of motor dysfunction of first onset and sphincter dysfunction of new emergence in course in LOMS group were significantly higher than those in LOMS group(P<0.05-0.01).The rates of sensory and visual disturbance of first onset,motor disturbance and vis... |
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| Keywords: | multiple sclerosis clinical features cerebrospinal fluid magnetic resonance imaging |
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