| 舒芬太尼与芬太尼对肝移植术患者血流动力学及应激反应影响的比较 |
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| 引用本文： | 宇鹏,韩曙君,雷志礼,安丽娜,宁新宇,董兰,王甜甜.舒芬太尼与芬太尼对肝移植术患者血流动力学及应激反应影响的比较[J].临床麻醉学杂志,2011,27(8). |
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| 作者姓名： | 宇鹏 韩曙君 雷志礼 安丽娜 宁新宇 董兰 王甜甜 |
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| 作者单位： | 中国武警总医院麻醉科, 北京市,100039 |
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| 摘 要： | 目的比较舒芬太尼与芬太尼对肝移植手术患者血流动力学及应激反应的影响。方法原位肝移植的终末期肝病患者50例,随机均分为两组,舒芬太尼组(S组)和芬太尼组(F组)诱导用药分别为舒芬太尼0.5~0.6μg/kg和芬太尼4~6μg/kg,分别以舒芬太尼0.8~1.5μg/kg和芬太尼10~15μg/kg维持麻醉。记录入室后(T1)、插管即刻(T2)、插管后5 min(T3)、无肝前期末(T4)、无肝期末(T5)、新肝期30 min(T6)、新肝期240 min或关腹时(T7)血流动力学指标及T1、T4~T7时的血清皮质醇(Cor)、血管紧张素I(AI)、血管紧张素Ⅱ(AⅡ)、内皮素(ET)和血糖(Glu)、血乳酸(Lac)浓度。结果 T3、T4时F组MAP显著低于S组(P<0.05)。与T4时比较,T5时两组MAP、CVP、CO均显著降低(P<0.01),HR显著增快(P<0.01)。与T5时比较,T6时两组MAP、CVP、CO均显著升高(P<0.05或P<0.01)。与T1时比较,T5时两组Cor、AⅠ、AⅡ、ET和乳酸均显著升高(P<0.05或P<0.01),T6时Cor、AⅠ、ET和乳酸仍明显升高(P<0.01...
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| 关 键 词： | 肝移植术 应激反应 舒芬太尼 芬太尼 血流动力学 |
Comparisons of hemodynamics and stress response between sufentanil and fentanyl during liver transplantation |
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| YU Peng,HAN Shu-jun,LEI Zhi-li,et al..Comparisons of hemodynamics and stress response between sufentanil and fentanyl during liver transplantation[J].The Journal of Clinical Anesthesiology,2011,27(8). |
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| Authors: | YU Peng HAN Shu-jun LEI Zhi-li |
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| Institution: | YU Peng,HAN Shu-jun,LEI Zhi-li,et al.Department of Anesthesiology,General Hospital of Chinese People's Armed Police Forces,Beijing100039,China |
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| Abstract: | Objective To compare the effects of sufentanil and fentanyl on hemodynamics and stress response during liver transplantation.Methods Fifty patients with chronic end-stage liver disease scheduled for liver transplantation were divided randomly into two groups.In group S(n= 25),anesthesia was induced with 0.5-0.6 g/kg sufentanil and maintained with 0.8-1.5 g/kg sufentanil;in group F(n=25),anesthesia was induced with 4-6 g/kg fentanyl and maintained with 10-15 g/kg fentanyl.Hemodynamic parameters were recorded... |
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| Keywords: | Liver transplantation Stress response Sufentanil Fentanyl Hemodynamics |
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