| 神经性厌食患者事件相关电位CNV的研究 |
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| 引用本文： | 陈珏,陈兴时,楼翡璎,肖泽萍,张明岛.神经性厌食患者事件相关电位CNV的研究[J].临床精神医学杂志,2011,21(6):378-380. |
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| 作者姓名： | 陈珏 陈兴时 楼翡璎 肖泽萍 张明岛 |
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| 作者单位： | 200030,上海交通大学医学院附属精神卫生中心 |
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| 基金项目： | 上海市卫生局科研基金(2008097) |
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| 摘 要： | 目的:探讨神经性厌食(AN)患者的事件相关电位CNV的特点以及认知功能损害的神经生物学机制。方法:应用美国Nicolet Spirit脑诱发电位仪,刺激采用纯音"Oddball"诱发模式,对43例AN患者(研究组)和34名健康对照(对照组)进行认知电位CNV的检测。结果:两组CNV主要指标比较,以研究组的PINV时程延长(t=2.44,P=0.02),波幅B降低(t=3.85,P=0.00)以及反应时间延长(t=-2.11,P=0.04);两组间比较,差异有统计学意义。两组CNV其他指标比较,潜伏期A(t=-1.76,P=0.08)、A-S2’(t=1.88,P=0.06)以及B时程(t=-0.65,P=0.52)差异均无统计学意义。结论:AN患者的CNV存在PINV时程延长、波幅B降低、反应时间延长,支持AN患者存在认知功能损害。
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| 关 键 词： | 神经性厌食 事件相关电位 认知功能 |
The experiment study of event-related potentials CNV in anorexia nervosa |
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| CHEN Jue
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CHEN Xing-shi
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LOU Fei-ying
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XIAO Ze-ping
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ZHANG Ming-dao.The experiment study of event-related potentials CNV in anorexia nervosa[J].Journal of Clinical Psychological Medicine,2011,21(6):378-380. |
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| Authors: | CHEN Jue CHEN Xing-shi LOU Fei-ying XIAO Ze-ping ZHANG Ming-dao |
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| Institution: | CHEN Jue,CHEN Xing-shi,LOU Fei-ying,XIAO Ze-ping,ZHANG Ming-dao.Shanghai Mental Health Center,Shanghai 200030,China |
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| Abstract: | Objective:To investigate the characteristics of event-related potentials contingent negative variation(CNV) and the neurobiology of cognitive dysfunction in the mechanism in patients with anorexia nervosa(AN) . Method:CNV were recorded in 43 AN patients(study group) and 34 health controls(control group) by the standard oddball paradigm presented with auditory double clicks stimuli,using American Nicolet Bravo instrument. Results:Compared with the control group,the study group showed the course of PINV was p... |
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| Keywords: | anorexia nervosa event-related potentials cognition function |
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