色氨酸羟化酶1与5-羟色胺2A受体基因对抑郁症患者额叶情绪加工的影响

目的:分析色氨酸羟化酶1 (TPH1)基因A218C多态性、5-羟色胺(5-HT)2A受体基因(HTR2A) T102C多态性对抑郁症患者额叶情绪识别功能异常的影响. 方法:28例抑郁症患者(患者组)及34名性别、年龄、受教育年限相匹配的健康对照(对照组)均进行情绪识别任务态下功能磁共振扫描,并以聚合酶链式反应-限制...

The impact of tryptophan hydroxylase 1 gene and serotonin receptor 2A gene on emotional process in depressive frontal lobe

Objective：To explore the genetic impact of tryptophan hydroxylase 1 gene（TPH1） A218C、serotonin receptor 2A gene（HTR2A） T102C on abnormal frontal lobe of depressed patients in emotion recognization. Method：28 patients with major depression and 34 healthy controls were recruited in our study,which were equal in sex,age,years of education.They all underwent functional magnetic resonance imaging（fMRI） in emotion recognition and were divided into different genotypes with the method of polymerase chain reaction and restriction fragment length polymorphism.The frontal lobe was extracted as region of interest by WFU software into six subregions to compare differences among different groups. Results：①In recognition of happy facial expression,activation of right middle frontal gyrus in patients with TPH1AA genotype was less than other five groups.Activation in patients with HTR2ACC genotype was less than patients and controls with AA or AC genotype（P0.05） .② In recognition of sad facial expression,patients and controls with TPH1AA genotype showed increased activation in left inferior frontal lobe than those with AC or CC genotype.Patients with AA genotype showed increased activation in right inferior frontal gyurs than other five groups as well.Patients with HTR2ACC genotype showed increase activation in right middle frontal gyrus than patients with TT of TC genotype and controls with TT genotype,showing increase activation in right inferior frontal gyrus than those with TT or TC genotype（P0.05） .③Superimposition of TPH1A218C and HTR2AT102C was found in abnormal function of right middle frontal gyrus when recognizing positive emotional stimuli and right inferior grontal gyrus when recognizing negative emotional stimuli（P0.05） . Conclusion：Frontal lobe in depressive disorder has the genetic basis of 5-HT to some extent Different genes in serotonin system can affect brain function through a common 5-HT feature.