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| 新疆维吾尔族帕金森病患者Parkin基因V/L380多态性研究 | |
| 引用本文： | 梁晨,杨新玲,彭颜晖,马青平.新疆维吾尔族帕金森病患者Parkin基因V/L380多态性研究[J].临床神经病学杂志,2011,24(5):338-340. |
| 作者姓名： | 梁晨 杨新玲 彭颜晖 马青平 |
| 作者单位： | 1. 833200,新疆奎屯农七师医院神经内科 2. 新疆医科大学第一附属医院神经医学中心 3. 新疆医科大学第六附属医院神经内科 |
| 基金项目： | 新疆维吾尔自治区自然科学基金(2009211A17) |
| 摘 要： | 目的 研究新疆维吾尔族帕金森病(PD)患者Parkin基因V/L380位点的多态性.方法 提取56例维吾尔族原发性PD患者(PD组)和82例维吾尔族健康对照者(正常对照组)的基因组DNA,采用PCR扩增所需Parkin基因第10外显子基因片段,用限制性内切酶酶切技术检测其Parkin基因V/L380位点的基因型和等位基... |
| 关 键 词： | 维吾尔族 帕金森病 Parkin基因 多态性 |
Investigation on the polymorphism of Parkin gene V/L380 in Uygur patients with Parkinson disease in Xinjiang |
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| Xin jiang,LIANG Chen,YANG Xin-ling,PENG Yan-hui.Investigation on the polymorphism of Parkin gene V/L380 in Uygur patients with Parkinson disease in Xinjiang[J].Journal of Clinical Neurology,2011,24(5):338-340. | |
| Authors: | Xin jiang LIANG Chen YANG Xin-ling PENG Yan-hui |
| Institution: | LIANG Chen,YANG Xin-ling,PENG Yan-hui,et al.Department of Neurology,the 7th Agricultural Division Hospital of Xinjiang Kuitun,Kuitun 833200,China |
| Abstract: | Objective To investigate the polymorphism of Parkin gene V/L380 in Uygur patients with Parkinson disease(PD)in Xinjiang.Methods The genetic DNA was extracted from 56 Uygur PD patients(PD group) and 82 Uygur healthy controls(normal control group).The exon 10 of Parkin gene was amplified by PCR.Then the restriction endonuclease method was used to detect the genotype and allele frequency of Parkin gene V/L380.And the results were compared between the two groups.Results The V/L380 CC genotype of Parkin gene was... |
| Keywords: | Uygur Parkinson disease Parkin gene polymorphism |
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