红细胞分布宽度与类风湿关节炎疾病程度的关系研究

目的 探讨红细胞分布宽度(RDW)与类风湿关节炎(RA)疾病程度的关系。方法 回顾性分析2013年01月～2016年12月在长江大学附属第一医院风湿免疫科收治的RA患者102例,收集病人的临床资料及RDW,红细胞沉降率(ESR),高敏C反应蛋白(hs-CRP),类风湿因子(RF)等指标。以ESR 40mm/h和hs-CRP 5 mg/L为界分为重度炎症组和轻度炎症组,以血红蛋白(HB)110g/L为界分为非贫血组和贫血组。采用t检验分别比较两组间各指标水平,采用Speraman分析对RDW,ESR,CRP和RF进行相关性研究。结果 ①RA患者ESR,hs-CRP和RF水平均明显升高; ②重度炎症组患者RDW和RF明显高于但HB,RBC水平明显低于轻度炎症组(P<0.05)。贫血组RDW,RF,ESR和hs-CRP水平明显高于非贫血组(P<0.05); ③RA患者中RDW与ESR,hs-CRP和RF有明显相关性(P<0.05),但非贫血组RA患者中RDW与ESR,hs-CRP和RF均无相关性(P>0.05)。结论 RA患者中RDW与疾病严重程度及炎症因子有相关性,但可能受到贫血的影响。

Relationship between Red Blood Cell Distribution Widthand Severity of Rheumatiod Arthritis

Abstract:Objective To investigate the relationship between red blood cell distribution width(RDW)and disease degree of aheumatiod arthritis(RA).Methods Selected 102 RA patients in Department of Rheumatology,the First Affilicated Hospital of Yangtze University from January 2013 to December 2016,and collected the clinical datas and the levels ofRDW,erythrocyte sedimentation rate(ESR),high-sensitivity C-reactive protein(hs-CRP)and rheumatoid factor(RF).The patients were divided into high inflammatory and low inflammatory groups on the basis of ESR(40 mm/h)and hs-CRP(5mg/L),and also were divided into nonanemic and anemic groups on the basis of HB(110 g/L).The differences of various factors among groups were evaluated by t test and relations between various factors were evaluated by Spearman correlation analysis.Results ①The levels of ESR,hs-CRP and RF were very high in RA patients.②RDW and RF levels were higher but HB and RBCwere lower in high inflammatory groups than in low inflammatory(P<0.05).RDW,RF,ESR and hs-CRP levels in anemic groups were higher than in nonanemic groups(P<0.05).③RDW was significantly associated with ESR,hs-CRP and RFin all RA patients,but was no associated with ESR,hs-CRP and RF in nonanemicgroups.Conclusion RDW was associated with the severityof disease and inflammatory factors in RA,but the relationship may be affectedby anemia.