血清免疫球蛋白检测在慢性乙型肝炎和乙肝肝硬化中的临床意义

目的 探讨血清免疫球蛋白IgA,IgM和IgG检测在慢性乙型肝炎(chronic hepatitis B,CHB)和乙肝肝硬化(chepatitis B cirrhosis,HBC)中的临床意义。方法 选取2017年1月～2018年3月在西安市中心医院治疗的CHB患者80例和HBC患者78例(代偿期55例和失代偿期23例)作为研究对象,另选取同期健康体检者80例作为对照组,应用免疫散射比浊法检测各组血清IgA,IgM和IgG水平。结果 CHB组血清IgA和IgG水平显著高于对照组,HBC组血清IgA,IgM和IgG水平显著高于对照组,HBC组血清IgA和IgG水平显著高于CHB组,差异具有统计学意义(t=2.009～6.804,均P<0.05)。肝硬化失代偿期组血清IgA水平显著高于代偿期组,差异具有统计学意义(t=2.333,P<0.05)。结论 血清免疫球蛋白检测对于CHB和HBC患者的病情判断、临床治疗及预后评估具有重要的临床意义。

Clinical Significance of Serum Immunoglobulin Detection in Chronic Hepatitis B and Hepatitis B Cirrhosis

Objective To investigate the clinical significance of serum immunoglobulin IgA, IgM and IgG detection in chronic hepatitis B(CHB)and hepatitis B cirrhosis(HBC).Methods 80 cases of CHB and 78 cases of HBC(55 cases in compensatory period and 23 cases in decompensatory period)in Xi'an Central Hospital from January 2017 to March 2018 were selected as the research subjects.In addition,80 healthy persons in the same period were selected as control group.The levels of serum IgA,IgM and IgG were detected by immunoturbidimetry.Results The levels of serum IgA and IgG in CHB group were significantly higher than those in control group,the levels of serum IgA,IgM andIgG in HBC group were significantly higher than those in control group,and the levels of serum IgA and IgG in HBC group were significantly higher than those in CHB group,the differences were statistically significant(t=2.009～6.804, all P<0.05).The level of serum IgA in decompensated cirrhosis group was significantly higher than that in compensated cirrhosis group,the difference was statistically significant(t=2.333,P<0.05).Conclusion Detectionof serum immunoglobulin has important clinical significance for the diagnosis,clinical treatment and prognosis evaluation of the patients with CHB andHBC.