补阳还五汤对心肌梗死后患者心脏重塑及心功能的作用研究

摘要 目的:研究补阳还五汤对心肌梗死后患者心脏重塑及心功能改善的作用。方法:选择130例心肌梗死患者临床资料，将其随机分为对照组和观察组，每组65例患者。对照组采用常规西药治疗，观察组在对照组治疗的基础上加服补阳还五汤，治疗5个疗程（1个月为1个疗程） 后观察对比两组患者心脏重塑及心功能改善情况。结果:观察组总有效率92.30%明显高于对照组76.92% （P＜0.05）；治疗后两组左室舒张末内径(LVDd)、左室收缩期内径(LVDs)、左室后壁厚度(LVPWT)、左室心肌重量(LVM)均明显改善，与治疗前对比（P＜0.05），且观察组改善明显优于对照组（P＜0.05）；治疗后两组左室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV)、每搏输出量(SV)、心搏量(CO)、射血分数(EF)、二尖瓣E波峰值流速/A波峰值流速(E/A)均明显改善，与治疗前对比（P＜0.05），且观察组改善明显优于对照组（P＜0.05）;治疗后两组中医临床症状评分明显降低，与治疗前对比（P＜0.05），且观察组明显低于对照组（P＜0.05）;观察组并发症发生率明显低于对照组，差异有统计学意义（P＜0.05）.结论:补阳还五汤对心肌梗死后患者心脏重塑及心功能改善具有显著的作用，改善心肌梗死患者预后，具有临床应用的重要意义。

Clinical study on Buyang Huanwu decoction on cardiac remodeling and cardiac function in patients with myocardial infarction

Abstract Objective:To study the effect of Buyang Huanwu decoction（BYHWD） on cardiac remodeling and cardiac function in patients with myocardial infarction. Methods: 130 patients with myocardial infarction were randomly divided into control group and observation group with 65 patients in each group. The control group was treated with conventional western medicine. The observation group was treated with BYHWD for 5 courses on the basis of the control group，and the improvement of cardiac remodeling and heart function were compared between the two groups . Results:The total effective rate in the observation group was 92.30%，significantly higher than that in the control group (76.92%,P＜0.05).After treatment，the left ventricular end diastolic diameter (LVDd)，left ventricular systolic diameter (LVDs)，left ventricular posterior wall thickness (LVPWT)，left ventricular weight (LVM) were significantly improved in the 2 groups，compared with before treatment (P＜0.05)，and the improvement in the observation group was significantly better than that in the control group (P＜0.05);2 groups of left ventricular end diastolic volume contraction after treatment (LVESV)，left ventricular end diastolic volume (LVEDV)，stroke volume (SV)，stroke volume (CO)，ejection fraction (EF)，the peak velocity of mitral E wave and /A wave peak flow velocity (E/A) were significantly improved，compared with before treatment (P＜0.05)，and the observation group improved significantly better than the control group (P＜0.05). Conclusion:Buyang Huanwu decoction in patients with myocardial infarction cardiac remodeling and improvement of cardiac function has a significant role in improving the prognosis of patients with myocardial infarction，with clinical significance.