中性粒细胞与淋巴细胞比值对初发溃疡性结肠炎鉴别诊断及其严重程度判断的临床意义

目的 评估中性粒细胞与淋巴细胞比值(NLR)对溃疡性结肠炎诊断的临床意义。方法 选取2009年6月～2016年6月就诊于上海长海医院的192例患者,其中溃疡性结肠炎患者97例,肠易激综合征患者95例。通过研究血常规中中性粒细胞与淋巴细胞比值(NLR),分析两组疾病NLR差异,并评价NLR对溃疡性结肠炎诊断的敏感度及特异度; 通过改良的Mayo评分系统评估溃疡性结肠炎疾病严重程度,并分别分析NLR在溃疡性结肠炎不同严重程度及不同病变部位之间的差异。结果 与肠易激综合征组相比,溃疡性结肠炎患者NLR显著增高,差异具有统计学意义(t=2.327,P<0.021); 诊断溃疡性结肠炎敏感度和特异度分别为69.1%和75.8%; NLR在溃疡性结肠炎严重程度之间差异有统计学意义(F=8.221,P=0.001); NLR在不同病变部位之间差异无统计学意义(F=0.737,P=0.483)。结论 NLR在溃疡性结肠炎与肠易激综合征鉴别诊断中具有一定价值和临床意义,并且可以判断溃疡性结肠炎的严重程度。

Clinical Significance of the Ratio of Neutrophil to Lymphocyte in the Differential Diagnosis of Primary Ulcerative Colitis and the Judgment of Its Severity

Abstract:Objective To investigate the clinical impact ofneutrophil to lymphocyte ratio(NLR)in the diagnosis of ulcerative colitis.Methods The study included 97 patients with ulcerative colitis(UC)and 95 patients with irritable bowel syndrome(IBS)from June 2009 to June 2016.The differences of NLR between the two groups were analyzed and the result of sensitivity and specificity were calculated.The differencesn of NLR were analyzed between the groups of different severity and in different lesionsseparately.Results NLR were significantly higher in ulcerative colitis than in irritable bowel syndrome(t=2.327,P<0.021).Sensitivity was 69.1% and specificity was 75.8%.There was statistic different in groups of different severity determination of newly diagnosed ulcerative colitis(F=8.221,P=0.001)and there was no statistic different between different lesions(F=0.737,P=0.483).Conclusion NLR is valuablein the diagnosis of UC and IBS can determine the degree of inflammation of ulcerative colitis.