乳化异氟醚预处理对兔缺血再灌注心肌血流动力学的影响

近年来研究表明吸入麻醉药异氟醚可模拟缺血预处理发挥心肌保护作用，减轻再灌注期心肌功能抑制。以脂肪乳为载体静脉注射的乳化异氟醚可产生麻醉作用，但是否也具有心肌保护作用，尚无报道。为了进一步研究乳化异氟醚预处理对心肌缺血的保护效应，本实验在兔心肌缺血再灌注模型上测定不同时点血流动力学的有关指标，旨在探讨乳化异氟醚预处理对兔缺血再灌注心肌的血流动力学影响。

Effects of emulsified isoflurane induced preconditioning on cardiac hemodynamics duing myocardiac ischemin-reperfusion injury in rabbits

Objective To investigate the protective effects of emulsified isoflurane induced preconditioning on ischemia-reperfusion injury in rabbit hearts in vivo. Methods Thirty-two healthy rabbits of male weighing 2 kg~2.5 kg were anesthetized with intramuscular Ketamine 70 mg/kg. The animals PaCO_2 was maintained at 35 mmHg~45 mmHg.The animals were randomly allocated to one of 4 groups of 8 animals in each group:control group received no pretreatment(C);and three groups were pretreated with lipid vehicle(L),isoflurane(I) and emulsified isofiurane(EI). Each group was subjected to 1 h occlusion of left anterior descending artery followed by 3 h reperfusion. The change of haemodynamics parameters was observed. Results There were no statistically significant different in HR,MAP,cardiac output (CO),left ventricular systolic pressure(LVSP),the maximum rate of left ventricular systolic pressure(+dp/dtmax ),left ventricular end-diastolic pressure(LVEDP)and rate-pressure products(RPP) among all groups during ischemia and early reperfusion period. LVSP in control group and lipid vehicle pretreatment proup were much lower while LVEDP higher than that in all precondition proups during the late reperfusion period(P<0.05),the other haemodynamics parameters were no statistically significant different(P>0.05).Conclusion Emulsified isoflurane-induced preconditioning as isoflurane significant myocardial protection against ischima-reperfusion injury in vivo rabbit hearts.