肾脏透析对凝血和纤溶功能的影响

目的 评价肾脏透析对机体凝血和纤溶功能的影响。方法 30例慢性肾功能衰竭行维持性血透患者,于透析前1小时,透析开始后1小时,透后1小时、透后3天,分别检测:血小板计数(PLT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fib)、组织纤溶酶原激活物(t-PA)、D-二聚体(D-D)。结果透析开始后PLT下降(P<0.05),PT延长(P<0.05),APTT显著延长(P<0.01),术后恢复,透析后t-PA和D-D增高(P<0.05)。结论 肾脏透析可启动患者内源性凝血途径和继发性纤溶。

Effect of Kidney Dialysis on the Activity of Blood Coagulation and Fibrinolysis

Objective To estimate the effect of kidney dialysis on the activity of blood coagulation and fibrinolysis. Methods 30 cases with chronic kidney function failure were given dialysis, their PLT, PT, APTT, TT, Fib, t - PA, D-D were measured 1 hour before dialysis, 1 hour after dialysis started, 1 hour and 3 days after dialysis finished. Results PLT started descending after dialysis began(P< 0.05) ,PT lasted longer and APTT lasted significantly longer but returned to normal after dialysis; t-PA and D-D increased(P< 0.05). Conclusions Kidney dialysis might start endogenesis coagulation and fibrinolysis in the patients.