儿童少年期精神分裂症患者汉语句子事件相关电位N400特征研究

目的探讨儿童少年期精神分裂症患者汉语句子事件相关电位N400(N400)特征。方法随机选择年龄在7-15岁之间符合DSM-IV精神分裂症标准患者36例作为观察组,与观察组年龄、性别相匹配的健康者36例作为对照组。2组予N400检测,分别比较N400潜伏期、波幅的差异。结果观察组FZ、CZ、PZ、OZ点潜伏期比对照组延长(P<0.05或P<0.01),FZ、CZ、PZ点波幅比对照组减低(P<0.05);观察组F3波幅比F4波幅低(P<0.05)。结论儿童少年期精神分裂症患者存在与语言加工有关的认知损害。

Study on the event-related potential N400 character of semantic matching of sentence-ending words in childhood and adolescent schizophrenia

Objective To study the event-related potential N400 character of semantic matching of sentence-ending words in childhood and adolescent schizophrenia.Methods Thirty-six patients(among 7～15 years old) with schizophrenia who were consistent with the diagnosic standard of DSM-IV for schizophrenia were enrolled as research group randomly and thirty-six healthy persons whose age and sex were no different from the reaearch group were selected as control group.Two groups were measured with the event-related potential N400 evoked by semantic matching of sentence-ending words.N400 latencies and amplitudes of two groups were compared with each other respectively.Results FZ,CZ,PZ,OZ site latency in research group is longer than that in control group(P<0.05 or 0.01).FZ,CZ and PZ site amplitude in research group are lower than in control group(P<0.05)and F3 site amplitude is lower than F4 site amplitude(P<0.05).Conclusion Childhood and adolescent schizophrenia present cognitive dysfunction involved in integrating the semantic context of all sentences.