Magnesium supplementation in Gitelman syndrome |
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| Authors: | A. Bettinelli E. Basilico M. G. Metta P. Borella P. Jaeger M. G. Bianchetti |
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| Affiliation: | (1) Second Department of Pediatrics, University of Milan, Milan, Italy, IT;(2) Department of Biomedical Sciences, Section of Hygiene and Microbiology, University of Modena, Modena, Italy, IT;(3) Policlinic of Medicine, University of Bern, Bern, Switzerland, CH;(4) Division of Pediatric Nephrology, University Children’s Hospital, Inselspital, CH-3010 Bern, Switzerland e-mail: mbianche@insel.ch, CH |
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| Abstract: | The metabolism of potassium and magnesium are closely linked (in situations where potassium and magnesium depletion coexist, magnesium restoration alone is sufficient to correct hypokalemia). Moreover, magnesium deficiency blunts the interplay between circulating calcium and the calciotropic hormones. Renal magnesium wasting, hypokalemia, alkalosis, hypocalciuria, and a tendency towards hypocalcemia characterize Gitelman syndrome. Plasma or intracellular potassium, circulating calcium, and calciotropic hormones were therefore investigated in eight patients (4 females, 4 males, aged 9–20 years) with Gitelman syndrome before and during oral supplementation with magnesium pyrrolidone carboxylate 30 mmol daily for 4 weeks. Magnesium supplementation significantly increased plasma and intracellular magnesium and plasma calcium, but failed to completely restore magnesium deficiency. In contrast, blood levels of parathyroid hormone and calcitriol and plasma and intracellular potassium were not modified following magnesium administration. Received: 15 October 1997 / Revised: 1 June 1998 / Accepted: 20 July 1998 |
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| Keywords: | Gitelman syndrome Magnesium deficiency Potassium deficiency Parathyroid hormone Vitamin D |
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