卵巢低反应周期的受精方式对助孕结局的影响

目的比较常规体外受精(IVF)和卵胞浆内单精子注射(ICSI)两种受精方式对无明确男性因素的周期获卵数仅为1-3个患者的治疗结局的影响。方法回顾性分析IVF-胚胎移植周期中获卵数1-3个周期共403个,按受精方式分为常规IVF组(336个周期)与ICSI组(67个周期)。比较两组受精率、正常受精率、完全不受精周期率及临床妊娠率的差异。结果 IVF组正常受精率为71.54%,低于ICSI组的80.31%(P<0.05)。IVF组完全不受精周期率、受精率、卵裂率、种植率和妊娠率分别为10.42%、85.50%、97.93%、26.00%和34.93%,ICSI组分别为10.45%、82.68%、98.01%、19.10%和26.32%,两组间差异无统计学意义(P>0.05)。结论鉴于使用ICSI技术并不能提高种植率及妊娠率,建议对于无明确男性因素的周期获卵1-3个的仍可采用IVF。

Effects of fertilization methods on pregnancy outcomes in extremely low oocyte retrieval cycles

Objective To compare the results of in vitro fertilization(IVF) and intracytoplasmic sperm injection(ICSI) in extremely low oocyte retrieval cycles.Methods A total of 403 infertile couples with one to three oocytes per retrieval was retrospectively analyzed,which were divided into two groups of IVF(conventional IVF,336 cycles) and ICSI(with ICSI,67 cycles).Fertilization rate and normal fertilization rate,cleavage rate,complete fertilization failure rates,and clinical pregnancy rate were compared.Results The normal fertilization rate was significantly higher in group ICSI than that in group IVF(80.31% vs.71.54%)(P<0.05).The fertilization rate,cleavage rate,complete fertilization failure rates,and clinical pregnancy rate were not significantly different between two groups.Conclusion ICSI can not improve implantation rate and pregnancy rate in the infertile couples with one to three oocytes per retrieval.It is suggested that IVF might be still suitable for those patients.