| 膀胱移行细胞癌中MTDH和Ki-67的表达及临床意义 |
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| 引用本文： | 周健,王增军,殷长军,华立新,张炜. 膀胱移行细胞癌中MTDH和Ki-67的表达及临床意义[J]. 江苏医药, 2012, 38(11): 1282-1284 |
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| 作者姓名： | 周健 王增军 殷长军 华立新 张炜 |
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| 作者单位： | 周健 (南京医科大学第一附属医院泌尿外科,江苏省,210029) ； 王增军 (南京医科大学第一附属医院泌尿外科,江苏省,210029) ； 殷长军 (南京医科大学第一附属医院泌尿外科,江苏省,210029) ； 华立新 (南京医科大学第一附属医院泌尿外科,江苏省,210029) ； 张炜 (南京医科大学第一附属医院泌尿外科,江苏省,210029) ； |
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| 摘 要： | 目的探讨异黏蛋白(MTDH)和增殖细胞核抗原Ki-67在膀胱移行细胞癌中的表达及其临床意义。方法采用免疫组化法检测60例膀胱移行细胞癌和15例正常膀胱组织中MTDH和Ki-67的表达。结果膀胱移行细胞癌组织中MTDH为65%;正常膀胱组织中无MTDH表达。膀胱移行细胞癌组织Ki-67表达阳性率显著高于正常膀胱组织(47%vs.6%)(P<0.05)。MTDH的表达与膀胱移行细胞癌的病理分级、临床分期及复发密切相关。MTDH和Ki-67增殖指数呈正相关。结论 MTDH的异常表达与膀胱移行细胞癌的发生、发展相关。
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| 关 键 词： | 异黏蛋白 增殖细胞核抗原Ki-67 膀胱移行细胞癌 |
Expression and clinical significance of MTDH and Ki-67 in bladder transitional cell carcinoma |
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| Affiliation: | ZHOU Jian,WANG Zengjun,YIN Changjun,et al.Department of Urology,Frist Affiliated Hospital,Nanjing Medical University,Nanjing 210029,CHINA |
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| Abstract: | Objective To study the expression and clinical significance of metadherin(MTDH) and Ki-67 in bladder transitional cell carcinoma.Methods The expressions of MTDH and Ki-67 were detected in 60 bladder transitional cell carcinoma samples(group A) and 15 normal bladder tissues(group B) by immunohistochemical method.Results The positive expression rate of MTDH in group A was 65%,which was zero in group B.The positive expression rate of Ki-67 was higher in group A than that in group B(47% vs.6%)(P<0.05).The expression of MTDH was closely related to stage and classification of bladder tumors.The expression of MTDH was positively correlated with the proliferation index of Ki-67(P<0.05).Conclusion The overexpression of MTDH may play a role in the development and progression of bladder transional cell carcinoma. |
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| Keywords: | Metadherin Ki-67 Bladder transitional cell carcinoma |
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