| ACE基因多态性与原发性高血压患者动脉硬化的相关性 |
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| 引用本文： | 唐康庭,门琛,贾坚,茆丽娜,占伊扬. ACE基因多态性与原发性高血压患者动脉硬化的相关性[J]. 江苏医药, 2012, 38(13): 1526-1528 |
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| 作者姓名： | 唐康庭 门琛 贾坚 茆丽娜 占伊扬 |
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| 作者单位： | 唐康庭 (南京医科大学第一附属医院老年医学科,江苏省,210029) ； 门琛 (南京医科大学第一附属医院老年医学科,江苏省,210029) ； 贾坚 (南京医科大学第一附属医院老年医学科,江苏省,210029) ； 茆丽娜 (南京医科大学第一附属医院老年医学科,江苏省,210029) ； 占伊扬 (南京医科大学第一附属医院老年医学科,江苏省,210029) ； |
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| 基金项目： | 江苏省"六大人才高峰"项目 |
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| 摘 要： | 目的探讨原发性高血压(EH)患者动脉硬化与血管紧张素转换酶(ACE)基因多态性的相关性。方法用全自动动脉硬化测量仪检测118例EH患者臂-踝脉搏传导速度(baPWV),并分为非动脉硬化组(28例)和动脉硬化组(90例)。采用Snapshot技术比较两组ACE基因的多态性分布。结果在携带ACE基因的三种基因型(II、ID、DD)EH患者之间,臂-踝脉搏传导速度无明显统计学差异(P>0.05)。结论 ACE基因多态性与EH患者动脉硬化无明显相关性。
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| 关 键 词： | 血管紧张素转化酶 基因多态性 原发性高血压 动脉硬化 |
Correlation between ACE gene polymorphism and atreriosclerosis in patients with essential hypertension |
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| Affiliation: | TANG Kangting,MEN Chen,JIA Jian,et al.Department of Cardiology,First Affiliated Hospital,Nanjing Medical University,Nanjing 210029,CHINA |
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| Abstract: | Objective To ivestigate the correlation of angiotension converting enzyme(ACE) gene polymorphism and atherosclerosis(AS) in patients with essential hypertension(EH).MethodsOn the basis of brachial-ankle pulse wave velocity(baPWV) measurement with Auto-survey atherosclerosis apparatus and age-baPWV curve,118 EH patients were divided into two groups of A(90 cases,with AS) and B(28 cases,without AS).Snapshot technology was used to classify ACE gene polymorphism and compare ACE gene polymorphism distribution in two groups.Results There was no significant difference in baPWV among the EH patients carrying the II,ID and DD alleles of ACE gene.Conclusion There is no significant correlation between ACE gene polymorphism and AS in the patients with EH. |
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| Keywords: | Angiotension converting enzyme Gene polymorphism Essential hypertension Atherosclerosis |
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