戊乙奎醚在肺叶切除术患者的应用

目的探讨戊乙奎醚在肺叶切除术患者的应用价值。方法 30例ASAⅠ-Ⅱ级男性肺叶切除患者分为A组(年龄65-75岁)和B组(年龄45-55岁),每组15例。A组术前20min、单肺通气时分别给予戊乙奎醚0.01、0.02mg/kg,B组术前20min、单肺通气时均给予阿托品0.01mg/kg。检测两组双肺通气(T1)时、单肺通气0、5、20min(T2、T3、T4)时的MAP、HR、潮气量(VT)、气道峰压(Ppeak)、PETCO2。结果与T1时及B组相比,A组T3、T4时VT明显增加(P<0.05);与T1时及A组相比,B组T3、T4时Ppeak明显增加(P<0.01);两组MAP、HR、PETCO2差异均无统计学意义。结论戊乙奎醚可以明显扩张肺叶切除术老年患者支气管,增加肺顺应性。

Clinical application of penehyclidine in patients undergoing pulmonary lobectomy

Objective To investigate the application outcomes of penehyclidine in the patients undergoing pulmonary lobectomy.Methods Thirty ASA Ⅰ-Ⅱ male patients undergoing pulmonary lobectomy were divided into groups of A(65-75 years old) and B(45-55 years old) with 15 cases each.The patients in group A received penehyclidine 0.01 mg/kg and 0.02 mg/kg at 20 minutes before surgery and beginning of one-lung ventilation,respectively,and those in group B were given atropine 0.01 mg/kg instead of penehyclidine as in group A.HR,MAP,tidal volume(VT),peak airway pressure(Ppeak) and PETCO2 at T1(two-lung ventilation),T2(one-lung ventilation),T3(5 min after one-lung ventilation) and T4(20 min after one-lung ventilation) were compared between two groups.Results Compared with T1 and group B,VT was increased at T3 and T4 in group A(P<0.05).Compared with T1 and group A,Ppeak was increased at T3 and T4 in group B(P<0.01).There was no significant difference in hemodynamic index and PETCO2 between two groups.ConclusionPenehyclidine can dilate the bronchi and increase lung compliance in aged patients undergoing pulmonary lobectomy.