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| 前列腺癌组织中血管生成的免疫组织化学观察 | |
| 引用本文： | 申永璋,林霞,项锋钢,申东亮.前列腺癌组织中血管生成的免疫组织化学观察[J].齐鲁医学杂志,2000,15(1):1-3. |
| 作者姓名： | 申永璋 林霞 项锋钢 申东亮 |
| 作者单位： | 1. 日照市人民医院泌尿外科,山东省日照市,276800 2. 青岛大学医学院病理解剖学教研室 3. 青岛大学医学院附属医院泌尿外科 |
| 摘 要： | （１）目的 探讨前列腺癌组织中血管生成与肿瘤生物学行之之间的关系；（２）方法 应用免疫组织化学ＬＳＡＢ法检测３８例前列腺癌组织中微血管密度（ＭＶＤ）。（３）结果 前列腺癌组织中微血管形态不一，分布呈异质性，高分化癌组织中ＭＶＤ明显低于低分化和未分化癌组织（Ｆ＝６．４８，ｑ＝３．８０，４．８６，Ｐ〈０．０５，０．０１）；发生转移的癌组织中ＭＶＤ明显高于未转移的癌组织（ｔ＝３．７６，Ｐ〈０．００１）， |
| 关 键 词： | 前列腺肿瘤 免疫组织化学 微血管密度 |
IMMUNOHISTOCHEMICAL STUDIES OF ANG IOGENESIS IN HUMAN PROSTATIC CANCER |
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| SHEN Yongzhang,LIN Xia,XIANG Fenggang,et al\.IMMUNOHISTOCHEMICAL STUDIES OF ANG IOGENESIS IN HUMAN PROSTATIC CANCER[J].Medical Journal of Qilu,2000,15(1):1-3. | |
| Authors: | SHEN Yongzhang LIN Xia XIANG Fenggang \ |
| Institution: | SHEN Yongzhang,LIN Xia,XIANG Fenggang,et al\ Department of Urology,Rizhao People's Hospital,Rizhao,Shandong 276800\, [ |
| Abstract: | Objective\ To investigate the biological significance of tumor angiogenesis in human prostatic cancer.\ Methods\ Microvessel density (MVD) in 38 cases of invasive prostatic cancer were detected using immunohistochemical techniques (LSAB).\ Results\ The morphology of tumor microvessel was obviously various. Microvessel density in highly differentiated prostatic cancer was significantly lower than that in poorly differentiated and undifferentiated prostatic cancer, respectively( F=6.48, q=3.80, 4.86, P <0.05, 0.01). In carcinoma, with positive lymph node metastasis, microvessel density was significantly higher than that in node negative carcinoma ( t=3.76,P <0.001).\ Conclusion\ The results suggest that angiogenesis assessed by MVD plays an important role in the invasion and metastasis of human prostatic cancer. |
| Keywords: | prostatic neoplasms neovascularization immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |