卡托普利对酸吸入所致急性肺损伤的影响

目的探讨卡托普利对稀盐酸吸入所致大鼠急性肺损伤的影响。方法将健康成年大鼠30只随机分为三组：对照组、急性肺损伤（ALI）组、卡托普利干预（CAP）组，每组各10只。三组均游离大鼠气管进行气管内置管．对ALI组、CAP组分别经气管滴入0．1mmol／L盐酸0．4mL／kg，5min后CAP组大鼠腹腔注射卡托普利5mg／kg，1．5h后各组均取血测定血清中肿瘤坏死因子-α（TNF—α）含量及动脉血血气的受影响程度，并取肺组织进行病理学研究。结果与对照组相比，ALI组和CAP组TNF-α含量均有增多（P〈0．05），动脉血二氧化碳分压（PaCO2）均有升高（P〈0．05），动脉血氧分压（PaO2）均有降低（P〈0．05）。与ALI组相比，CAP组TNF—α含量明显减少（P〈0．05），PaCO，明显降低（P〈0．05），PaO2明显升高（P〈0．05）。结论稀盐酸滴人大鼠气管可致大鼠发生急性肺损伤。并在大鼠血清中可以测到TNF—α的含量明显升高，卡托普利可以减少大鼠急性肺损伤时血清中TNF—α含量．减轻肺组织的损伤。

Effects of Captopril on acute lung injury induced by acid-inhalation

Objective To investigate the effect of Captopril on dilute hydrochloric acid aspiration caused by the impact of acute lung iniury. Methods 30 healthy adult rats were randomly divided into three groups： control group, acute lung injury （ALI） group, Captopril （CAP） group. The trachea of all three groups was dissociated to take tracheal built-in tube, ALI group, CAP group were dropped in 0.1 mmol/L hydrochloric acid 0.4 mL/kg through trachea respectively, after 5 min, the rats of CAP group were given intraperitoneal injection of Captopril 5 mg/kg, after 1.5 h, the blood samples were collected to test the content of serum TNF-α and the influence of arterial blood gas, and the lung tissue was collected for pathology research. Results Compared with control group, TNF-α contents of ALI group and CAP group were increased （P 〈 0.05） and PaCO2 was improved （P 〈 0.05）, PaO2 was decreased （P 〈 0.05）. Compared with the ALI group, the TNF-α level in CAP group was decreased significantly （P 〈 0.05）, and PaCO2 decreased significantly （P 〈 0.05）, PaO2 was significantly increased （P 〈 0.05）. Conclusion Diluted hydrochloric acid dropped in trachea can lead to acute lung injury of rats, and the level of TNF-α can be measured in serum of rats, Captopril can reduce the content of TNF-α during the period of acute lung injury, mitigate the damage of the lung tissue.