Shy-Drager综合征5例临床分析

Shy—Drager综合征（SDS）是一种累及自主神经系统的少见疾病，因其症状复杂常被漏诊、误诊。本研究回顾性分析了5例SDS患者的临床资料。5例患者均有直立性低血压的临床表现，3例出现阳萎，4例出现锥体外系、小脑、脑干等损害症状；MRI检查显示，5例患者均有不同程度的小脑或脑干萎缩；2例脑干诱发电位出现一侧I～Ⅲ峰间期延长；2例肛门括约肌肌电图提示神经源性肌电改变。卧立位血压测量及详细查体对SDS诊断具有重要意义，中西医结合治疗对发病早期患者有一定的效果，但晚期预后不良。

Clinical analysis of Shy-Drager syndrome in 5 cases

Shy-Drager syndrome （SDS） is a rare neurological disease involving autonomic nerves system. The patients with SDS are very often misdiagnosed because of complexity of symptoms. This study analyzes clinical data of 5 cases with SDS retrospectively. All patients have clinical manifestations of orthostatic hypotension. 3 cases have impotence and 4 cases have extrapyramidal, cerebellar, or brain stem damage symptoms. MRI shows that 5 cases have cerebellar or brain stem atrophy. 2 cases demonstrate unilateral I -1I peak interval prolongation. 2 cases of EAS-EMG show neurogenic changes. Lying orthostatic blood pressure measurement and careful examination are the most important for diagnosis. Combined treatment of traditional chinese medicine and western medicine maybe provide some help for treament, but the later prognosis is poor.